Sugi Predict

Sugi Predict / Compounds / SCHEMBL191236

SCHEMBL191236

SCHEMBL191236

CC(C)(C)[Si](C)(C)OCCC(N)C(=O)O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NOS3 P29474 1/20 0.41
▸ NOS1 P29475 1/20 0.41
▸ NOS2 P35228 1/20 0.41
▸ ALDH1A1 P00352 1/20 0.40
▸ SLC1A2 P43004 4/20 0.40
▸ SLC1A1 P43005 4/20 0.40
▸ SLC1A3 P43003 3/20 0.40
▸ GRIK1 P39086 4/20 0.39
▸ GRIK2 Q13002 4/20 0.39
▸ GSR P00390 2/20 0.39
▸ SLC7A5 Q01650 1/20 0.39
▸ GRM8 O00222 1/20 0.39
▸ GRM6 O15303 1/20 0.39
▸ GRIN2D O15399 1/20 0.39
▸ GRIN3B O60391 1/20 0.39
▸ CYP1A2 P05177 1/20 0.39
▸ GRM5 P41594 1/20 0.39
▸ GRIA1 P42261 1/20 0.39
▸ GRIA2 P42262 1/20 0.39
▸ GRIA3 P42263 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL191235 1.00 NOS3 (0.41) NOS3NOS1NOS2ALDH1A1SLC1A2
SCHEMBL490891 1.00 NOS3 (0.41) NOS3NOS1NOS2ALDH1A1SLC1A2
SCHEMBL28580283 0.90 GSR (0.43) NOS3NOS1NOS2ALDH1A1GSR
SCHEMBL13639864 0.84 SLC1A1 (0.55) SLC1A2SLC1A1SLC1A3GRIK1GRIK2
SCHEMBL19699429 0.83 IDO1 (0.34) SLC1A1
SCHEMBL1067509 0.83 IDO1 (0.34) SLC1A1
SCHEMBL1067514 0.83 IDO1 (0.34) SLC1A1
SCHEMBL30980082 0.83 IDO1 (0.34) SLC1A1
SCHEMBL10314812 0.81 NOS3 (0.38) NOS3NOS1NOS2ALDH1A1SLC1A2
SCHEMBL20591675 0.81 NOS3 (0.38) NOS3NOS1NOS2ALDH1A1SLC1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3761989-B1 IMIDAZODIAZEPINEDIONES AND METHODS OF USE THEREOF GFB ABC LLC (US) 2026-05-13 — — EP disclosed
US-12466834-B2 Imidazodiazepinediones and methods of use thereof GFB (ABC), LLC (US) 2025-11-11 — — US disclosed
CN-118908961-A Imidazodiazepine diketones and methods of use thereof 金翅雀生物公司 2024-11-08 — — CN disclosed
CN-112351781-B Imidazodiazepine diketones and methods of use thereof 金翅雀生物公司 2024-07-02 — — CN disclosed
US-20230365575-A1 IMIDAZODIAZEPINEDIONES AND METHODS OF USE THEREOF GFB (ABC), LLC 2023-11-16 — — US disclosed
US-20230365575-A1 IMIDAZODIAZEPINEDIONES AND METHODS OF USE THEREOF GFB (ABC), LLC 2023-11-16 — — US disclosed
EP-4198029-A1 INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF University Health Network (CA) 2023-06-21 — — EP disclosed
US-11623930-B2 Imidazodiazepinediones and methods of use thereof GOLDFINCH BIO, INC. (US) 2023-04-11 — — US disclosed
US-11623930-B2 Imidazodiazepinediones and methods of use thereof GOLDFINCH BIO, INC. (US) 2023-04-11 — — US disclosed
EP-3337791-B1 INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF UNIV HEALTH NETWORK (CA) 2022-08-03 — — EP disclosed
WO-2006117567-A2 ALPHA AMINOACID ESTER-DRUG CONJUGATES HYDROLYSABLE BY CARBOXYLESTERASE CHROMA THERAPEUTICS LTD (GB) 2006-11-09 — — WO disclosed
WO-2006117548-A1 HYDROXAMIC ACID DERVICATIVES AS INHIBITORS OF HDAC ENZYMATIC ACTIVITY CHROMA THERAPEUTICS LTD (GB) 2006-11-09 — — WO disclosed
US-7087759-B2 for controlling weight; pyrrolidine or piperidine compounds THE PROCTER & GAMBLE COMPANY (US) 2006-08-08 — — US disclosed
US-20060106059-A1 Melanocortin receptor ligands MAZUR WIESLAW A 2006-05-18 — — US disclosed
EP-1390361-A4 MELANOCORTIN RECEPTOR LIGANDS PROCTER & GAMBLE (US) 2005-10-05 — — EP disclosed
US-6911447-B2 Melanocortin receptor ligands THE PROCTER & GAMBLE COMPANY (US) 2005-06-28 — — US disclosed
US-20040224985-A1 Melanocortin receptor ligands THE PROCTER & GAMBLE COMPANY 2004-11-11 — — US disclosed
EP-1390361-A2 MELANOCORTIN RECEPTOR LIGANDS THE PROCTER & GAMBLE COMPANY (US) 2004-02-25 — — EP disclosed
US-20030109556-A1 Melanocortin receptor ligands THE PROCTER & GAMBLE COMPANY 2003-06-12 — — US disclosed
WO-2002085925-A2 MELANOCORTIN RECEPTOR LIGANDS THE PROCTER & GAMBLE COMPANY (US) 2002-10-31 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230365575-A1 IMIDAZODIAZEPINEDIONES AND METHODS OF USE THEREOF REN, ATP6V1B1, GLS NOS3 2739/4885NOS1 3931/4885NOS2 2436/4885
US-20030109556-A1 Melanocortin receptor ligands MC3R, MC4R, MC1R NOS3 2570/4885NOS1 4532/4885NOS2 4575/4885
US-11623930-B2 Imidazodiazepinediones and methods of use thereof REN, ATP6V1B1, GLS NOS3 2739/4885NOS1 3931/4885NOS2 2436/4885
US-20060106059-A1 Melanocortin receptor ligands MC3R, MC4R, MC1R NOS3 2007/4885NOS1 4430/4885NOS2 4013/4885
US-20040224985-A1 Melanocortin receptor ligands MC3R, MC4R, MC1R NOS3 2570/4885NOS1 4532/4885NOS2 4575/4885
US-12466834-B2 Imidazodiazepinediones and methods of use thereof REN, ATP6V1B1, GLS NOS3 2739/4885NOS1 3931/4885NOS2 2436/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.