Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | NTSR1 | P30989 | 3/20 | 0.36 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.36 |
| ▸ | TUBB | P07437 | 2/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.36 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22042149 | 0.79 | GLO1 (0.43) | MTNR1AMTNR1B | |
| SCHEMBL5637363 | 0.79 | ATM (0.56) | ATMMTNR1AMTNR1BHDAC8HDAC6 | |
| SCHEMBL9200019 | 0.77 | MTNR1A (0.60) | ATMMTNR1AMTNR1BHDAC8HDAC6 | |
| SCHEMBL5449877 | 0.77 | ATM (0.57) | ATMMTNR1AMTNR1BHDAC8HDAC6 | |
| SCHEMBL19674140 | 0.77 | ATM (0.57) | ATMMTNR1AMTNR1BHDAC8HDAC6 | |
| SCHEMBL14876504 | 0.76 | NTSR1 (0.57) | ATMMTNR1AMTNR1BHDAC8HDAC6 | |
| SCHEMBL21810428 | 0.76 | NTSR1 (0.57) | ATMMTNR1AMTNR1BHDAC8HDAC6 | |
| SCHEMBL19126497 | 0.75 | LOXL2 (0.43) | KDM4EALDH1A1 | |
| SCHEMBL14594510 | 0.75 | ATM (0.55) | ATMMTNR1AMTNR1BHDAC8HDAC6 | |
| SCHEMBL6029964 | 0.75 | ATM (0.58) | ATMMTNR1AMTNR1BHDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11939314-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2024-03-26 | — | — | US | disclosed |
| US-20230028687-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-01-26 | — | — | US | disclosed |
| US-11186562-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2021-11-30 | — | — | US | disclosed |
| US-11174241-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2021-11-16 | — | — | US | disclosed |
| CN-108473485-B | Quinolin-2-one derivatives | 默克专利股份公司 | 2021-11-02 | — | — | CN | disclosed |
| US-20200190054-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-06-18 | — | — | US | disclosed |
| US-20200190055-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-06-18 | — | — | US | disclosed |
| US-10669251-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2020-06-02 | — | — | US | disclosed |
| US-20190023685-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-01-24 | — | — | US | disclosed |
| EP-3402792-A1 | QUINOLIN-2-ONE DERIVATIVES | Merck Patent GmbH (DE) | 2018-11-21 | — | — | EP | disclosed |
| WO-2017121444-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11174241-B2 | Quinolin-2-one derivatives | KIT, CDK2, CDK1 | ATM 419/4885MTNR1A 1953/4885MTNR1B 1834/4885 |
| US-20190023685-A1 | QUINOLIN-2-ONE DERIVATIVES | KIT, CDK2, CDK1 | ATM 419/4885MTNR1A 1953/4885MTNR1B 1834/4885 |
| US-20200190054-A1 | QUINOLIN-2-ONE DERIVATIVES | KIT, CDK2, CDK1 | ATM 419/4885MTNR1A 1953/4885MTNR1B 1834/4885 |
| US-11939314-B2 | Quinolin-2-one derivatives | KIT, CDK2, CDK1 | ATM 419/4885MTNR1A 1953/4885MTNR1B 1834/4885 |
| US-20230028687-A1 | QUINOLIN-2-ONE DERIVATIVES | KIT, CDK2, CDK1 | ATM 419/4885MTNR1A 1953/4885MTNR1B 1834/4885 |
| US-20200190055-A1 | QUINOLIN-2-ONE DERIVATIVES | KIT, CDK2, CDK1 | ATM 419/4885MTNR1A 1953/4885MTNR1B 1834/4885 |
| US-10669251-B2 | Quinolin-2-one derivatives | KIT, CDK2, CDK1 | ATM 419/4885MTNR1A 1953/4885MTNR1B 1834/4885 |
| US-11186562-B2 | Quinolin-2-one derivatives | KIT, CDK2, CDK1 | ATM 419/4885MTNR1A 1953/4885MTNR1B 1834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.