Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.36 |
| ▸ | SREBF2 | Q12772 | 13/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ATM | Q13315 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20143958 | 0.75 | LMNA (0.40) | ALDH1A1LMNAHRH1 | |
| SCHEMBL12394763 | 0.74 | HRH4 (0.40) | ALDH1A1KDM4ELMNA | |
| SCHEMBL24868449 | 0.71 | ALDH1A1 (0.34) | ALDH1A1KDM4ELMNA | |
| SCHEMBL22291830 | 0.71 | CHRM1 (0.31) | CHRM1HRH1KCNH2 | |
| SCHEMBL13533992 | 0.69 | KDM4E (0.50) | SREBF2MAPTATML3MBTL1ALDH1A1 | |
| SCHEMBL21011913 | 0.69 | SMN1; SMN2 (0.38) | CACNA2D1MAPTL3MBTL1ALDH1A1CHRM1 | |
| SCHEMBL23075056 | 0.69 | SPHK2 (0.37) | CACNA2D1L3MBTL1KDM4ELMNACHRM1 | |
| SCHEMBL19706016 | 0.68 | SLC6A3 (0.40) | MAPTL3MBTL1ALDH1A1LMNA | |
| SCHEMBL3549889 | 0.68 | GRM5 (0.36) | CACNA2D1MAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL20280911 | 0.68 | HRH1 (0.46) | SREBF2L3MBTL1ALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9708331-B2 | Metabotrophic glutamate receptor 5 modulators and methods of use thereof | SUNOVION PHARMACEUTICALS INC. (US) | 2017-07-18 | — | — | US | disclosed |