Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.47 |
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8119586 | 0.80 | TSHR (0.64) | TSHRSMN1; SMN2MAPTLMNAHTT | |
| SCHEMBL327856 | 0.78 | CCR3 (0.66) | PRMT6CCR3CARM1 | |
| SCHEMBL22340469 | 0.77 | SMN1; SMN2 (0.54) | SLC6A2SLC6A4TSHRSMN1; SMN2MAPT | |
| SCHEMBL7241082 | 0.76 | SLC6A2 (0.71) | SLC6A2SLC6A4TSHRSMN1; SMN2MAPT | |
| SCHEMBL10502431 | 0.74 | TSHR (0.54) | TSHRSMN1; SMN2MAPTLMNANPC1 | |
| SCHEMBL3436965 | 0.73 | PRMT6 (0.62) | SLC6A2SLC6A4PRMT6CCR3CARM1 | |
| SCHEMBL14503465 | 0.72 | TSHR (0.74) | TSHRSMN1; SMN2MAPTLMNAHTT | |
| SCHEMBL22324836 | 0.71 | SMN1; SMN2 (0.50) | SLC6A2SLC6A4TSHRSMN1; SMN2MAPT | |
| SCHEMBL3540368 | 0.70 | SLC6A2 (0.63) | SLC6A2SLC6A4TSHRSMN1; SMN2MAPT | |
| SCHEMBL5596598 | 0.70 | TSHR (0.56) | TSHRSMN1; SMN2MAPTLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9708305-B2 | Substituted 1,2,3,4-tetrahydroisoquinoline derivatives for the treatment of hormone-dependent diseases | UNIVERSITé LAVAL (CA) | 2017-07-18 | — | — | US | disclosed |