Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 4/20 | 0.39 |
| ▸ | CNR2 | P34972 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RARA | P10276 | 3/20 | 0.38 |
| ▸ | RARB | P10826 | 2/20 | 0.38 |
| ▸ | RARG | P13631 | 2/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1913928 | 0.91 | IKBKB (0.41) | SMN1; SMN2NPC1RAB9AS1PR1HPGD | |
| SCHEMBL1914117 | 0.86 | RARA (0.41) | S1PR1LMNAMEN1KMT2ARARA | |
| SCHEMBL13505600 | 0.85 | HDAC11 (0.45) | S1PR1LMNAALDH1A1TP53GAA | |
| SCHEMBL13505534 | 0.85 | HDAC11 (0.45) | S1PR1LMNAALDH1A1TP53GAA | |
| SCHEMBL1914439 | 0.85 | XDH (0.43) | SMN1; SMN2NPC1RAB9AS1PR1HPGD | |
| SCHEMBL1914546 | 0.84 | FAAH (0.44) | SMN1; SMN2NPC1RAB9AS1PR1HPGD | |
| SCHEMBL1913982 | 0.82 | LMNA (0.42) | SMN1; SMN2NPC1RAB9AS1PR1HPGD | |
| SCHEMBL1914162 | 0.81 | RARA (0.42) | SMN1; SMN2NPC1RAB9AS1PR1HPGD | |
| SCHEMBL1914344 | 0.80 | XDH (0.40) | SMN1; SMN2NPC1RAB9AHPGDLMNA | |
| SCHEMBL1913919 | 0.78 | IKBKB (0.40) | SMN1; SMN2NPC1RAB9AS1PR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096544-B2 | Therapeutic compounds | WAYNE STATE UNIVERSITY (US) | 2015-08-04 | — | — | US | disclosed |
| US-20130137699-A1 | THERAPEUTIC COMPOUNDS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2013-05-30 | — | — | US | disclosed |
| WO-2011079305-A1 | THERAPEUTIC COMPOUNDS | WAYNE STATE UNIVERSITY (US) | 2011-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137699-A1 | THERAPEUTIC COMPOUNDS | BAX, MCL1, TMBIM6 | SMN1; SMN2 1427/4885NPC1 46/4885RAB9A 989/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.