Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | PDE3B | Q13370 | 9/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.49 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.48 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.48 |
| ▸ | MPO | P05164 | 2/20 | 0.47 |
| ▸ | XDH | P47989 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1394736 | 0.87 | MTNR1A (0.44) | KDM4EALDH1A1HPGDSMN1; SMN2PDE3B | |
| SCHEMBL19146292 | 0.84 | PDE3B (0.54) | KDM4EALDH1A1HPGDSMN1; SMN2PDE3B | |
| SCHEMBL30462976 | 0.79 | PDE3B (0.56) | KDM4EALDH1A1HPGDSMN1; SMN2PDE3B | |
| SCHEMBL29030287 | 0.79 | PDE3B (0.56) | KDM4EALDH1A1HPGDSMN1; SMN2PDE3B | |
| SCHEMBL26035451 | 0.78 | GRIN2D (0.45) | KDM4EALDH1A1HPGDSMN1; SMN2GRIN2D | |
| SCHEMBL8944835 | 0.76 | PDE3B (0.52) | KDM4EALDH1A1HPGDSMN1; SMN2PDE3B | |
| SCHEMBL19146396 | 0.73 | NQO2 (0.60) | KDM4EALDH1A1HPGDSMN1; SMN2PDE3B | |
| SCHEMBL7983948 | 0.72 | KDM4E (0.61) | KDM4EALDH1A1HPGDSMN1; SMN2PDE3B | |
| SCHEMBL31195781 | 0.72 | KDM4E (0.61) | KDM4EALDH1A1HPGDSMN1; SMN2PDE3B | |
| SCHEMBL5534060 | 0.72 | GRIN2D (0.50) | KDM4EALDH1A1HPGDSMN1; SMN2PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11731960-B2 | Biheterocyclic compound | Sumitomo Pharma Co., Ltd. (JP) | 2023-08-22 | — | — | US | disclosed |
| US-20220380353-A1 | BIHETEROCYCLIC COMPOUND | Sumitomo Pharma Co., Ltd. (JP) | 2022-12-01 | — | — | US | disclosed |
| US-20210198242-A1 | BIHETEROCYCLIC COMPOUND | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2021-07-01 | — | — | US | disclosed |
| US-10870642-B2 | Biheterocyclic compound | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2020-12-22 | — | — | US | disclosed |
| US-20190308958-A1 | BIHETEROCYCLIC COMPOUND | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2019-10-10 | — | — | US | disclosed |
| US-10323024-B2 | Biheterocyclic compound | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2019-06-18 | — | — | US | disclosed |
| US-20190016711-A1 | BIHETEROCYCLIC COMPOUND | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2019-01-17 | — | — | US | disclosed |
| WO-2017122722-A1 | BIHETEROCYCLIC COMPOUND | 大日本住友製薬株式会社 | 2017-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220380353-A1 | BIHETEROCYCLIC COMPOUND | NPY4R, NR4A3, OGFR | KDM4E 883/4885ALDH1A1 3596/4885HPGD 3175/4885 |
| US-11731960-B2 | Biheterocyclic compound | NR4A3, NGF, OGFR | KDM4E 1008/4885ALDH1A1 3217/4885HPGD 3232/4885 |
| US-20210198242-A1 | BIHETEROCYCLIC COMPOUND | NR4A3, NGF, OGFR | KDM4E 1008/4885ALDH1A1 3217/4885HPGD 3232/4885 |
| US-20190308958-A1 | BIHETEROCYCLIC COMPOUND | NR4A3, NGF, OGFR | KDM4E 1008/4885ALDH1A1 3217/4885HPGD 3232/4885 |
| US-10323024-B2 | Biheterocyclic compound | NR4A3, NGF, OGFR | KDM4E 1008/4885ALDH1A1 3217/4885HPGD 3232/4885 |
| US-10870642-B2 | Biheterocyclic compound | NR4A3, NGF, OGFR | KDM4E 1008/4885ALDH1A1 3217/4885HPGD 3232/4885 |
| US-20190016711-A1 | BIHETEROCYCLIC COMPOUND | NR4A3, NGF, OGFR | KDM4E 1008/4885ALDH1A1 3217/4885HPGD 3232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.