Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | GPR183 | P32249 | 1/20 | 0.47 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19172946 | 0.95 | HSD11B1 (0.60) | HSD11B1ALDH1A1KMT2AMEN1TSHR | |
| SCHEMBL19173469 | 0.85 | HSD11B1 (0.52) | HSD11B1ALDH1A1KMT2AMEN1TSHR | |
| SCHEMBL5080239 | 0.74 | KMT2A (0.78) | ALDH1A1KMT2AMEN1TSHRSMN1; SMN2 | |
| SCHEMBL611401 | 0.73 | ALDH1A1 (0.68) | HSD11B1ALDH1A1KMT2AMEN1TSHR | |
| SCHEMBL12443568 | 0.72 | TFPI2 (0.50) | ALDH1A1KMT2AMEN1TSHRSMN1; SMN2 | |
| SCHEMBL9510221 | 0.72 | ALDH1A1 (0.62) | ALDH1A1KMT2AMEN1TSHRSMN1; SMN2 | |
| SCHEMBL1143256 | 0.72 | SIGMAR1 (0.60) | HSD11B1ALDH1A1KMT2AMEN1TSHR | |
| SCHEMBL13556913 | 0.72 | ALDH1A1 (0.53) | ALDH1A1KMT2AMEN1TSHRSMN1; SMN2 | |
| SCHEMBL2850013 | 0.71 | ALDH1A1 (0.70) | ALDH1A1KMT2AMEN1TSHRSMN1; SMN2 | |
| SCHEMBL10825084 | 0.71 | ALDH1A1 (0.70) | ALDH1A1KMT2AMEN1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3405183-A1 | ADAMATANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTION | Arisan Therapeutics Inc. (US) | 2018-11-28 | — | — | EP | disclosed |
| WO-2017127306-A1 | ADAMATANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTION | ARISAN THERAPEUTICS (US) | 2017-07-27 | — | — | WO | disclosed |