Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | PYCR1 | P32322 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2253179 | 0.84 | HRH3 (0.70) | ALDH1A1HRH3PYCR1CNR2KDM4E | |
| SCHEMBL131361 | 0.83 | ALDH1A1 (0.67) | ALDH1A1TSHRTRPA1HRH3CES2 | |
| SCHEMBL28591842 | 0.80 | ALDH1A1 (0.48) | ALDH1A1TSHRTRPA1HRH3PYCR1 | |
| Bromide SCHEMBL29980639 | 0.79 | ALDH1A1 (0.62) | ALDH1A1TSHRTRPA1HRH3CES2 | |
| SCHEMBL29083510 | 0.79 | PYCR1 (0.64) | ALDH1A1HRH3PYCR1KDM4ETAAR1 | |
| Trimethylammonium SCHEMBL3792932 | 0.78 | ALDH1A1 (0.53) | ALDH1A1TSHRTRPA1HRH3PYCR1 | |
| SCHEMBL12049793 | 0.75 | CNR2 (0.64) | ALDH1A1TSHRTRPA1HRH3CNR2 | |
| SCHEMBL2220712 | 0.73 | TRPA1 (0.56) | ALDH1A1TSHRTRPA1CES2CES1 | |
| SCHEMBL5885289 | 0.73 | ALDH1A1 (0.56) | ALDH1A1TSHRTRPA1CES2CES1 | |
| SCHEMBL679626 | 0.73 | TSHR (0.56) | ALDH1A1TSHRTRPA1HRH3CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11396530-B2 | Bicyclic peptide ligands and uses thereof | BICYCLETX LIMITED (GB) | 2022-07-26 | — | — | US | disclosed |
| US-20210147484-A1 | BICYCLIC PEPTIDE LIGANDS AND USES THEREOF | BICYCLETX LIMITED (GB) | 2021-05-20 | — | — | US | disclosed |
| US-10919937-B2 | Bicyclic peptide ligands and uses thereof | BICYCLETX LIMITED (GB) | 2021-02-16 | — | — | US | disclosed |
| US-10906932-B2 | Cyclising peptides | THE UNIVERSITY OF DURHAM (GB) | 2021-02-02 | — | — | US | disclosed |
| US-20200131228-A1 | BICYCLIC PEPTIDE LIGANDS AND USES THEREOF | BICYCLETX LIMITED (GB) | 2020-04-30 | — | — | US | disclosed |
| US-20170204134-A1 | Cyclising Peptides | THE UNIVERSITY OF DURHAM (GB) | 2017-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10906932-B2 | Cyclising peptides | VIP, NGLY1, NPPA | ALDH1A1 4866/4885TSHR 568/4885TRPA1 3895/4885 |
| US-20200131228-A1 | BICYCLIC PEPTIDE LIGANDS AND USES THEREOF | VIP, NGLY1, BID | ALDH1A1 4861/4885TSHR 1216/4885TRPA1 1202/4885 |
| US-20210147484-A1 | BICYCLIC PEPTIDE LIGANDS AND USES THEREOF | VIP, NGLY1, BID | ALDH1A1 4861/4885TSHR 1216/4885TRPA1 1202/4885 |
| US-10919937-B2 | Bicyclic peptide ligands and uses thereof | VIP, NGLY1, BID | ALDH1A1 4861/4885TSHR 1216/4885TRPA1 1202/4885 |
| US-11396530-B2 | Bicyclic peptide ligands and uses thereof | VIP, NGLY1, BID | ALDH1A1 4861/4885TSHR 1216/4885TRPA1 1202/4885 |
| US-20170204134-A1 | Cyclising Peptides | VIP, NGLY1, NPPA | ALDH1A1 4866/4885TSHR 568/4885TRPA1 3895/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.