Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | HTR1D | P28221 | 3/20 | 0.48 |
| ▸ | HTR1B | P28222 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | HTR1F | P30939 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19157407 | 0.93 | HTR1A (0.56) | RORCHTR1AHTR1DHTR1BATM | |
| SCHEMBL19157247 | 0.86 | RORC (0.49) | RORCHTR1AHTR1DHTR1BKCNH2 | |
| SCHEMBL21844837 | 0.85 | HTR2A (0.47) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL20083987 | 0.82 | RORC (0.57) | RORCACKR3 | |
| SCHEMBL20083978 | 0.80 | ACKR3 (0.43) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL21844944 | 0.78 | HTR1A (0.54) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL20083988 | 0.77 | RORC (0.48) | RORCHTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL15276824 | 0.77 | TSHR (0.60) | MEN1KMT2A | |
| SCHEMBL19157408 | 0.76 | MEN1 (0.51) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL13150784 | 0.74 | MEN1 (0.64) | HTR2AKCNH2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794565-B1 | HEPATITIS B ANTIVIRAL AGENTS | NOVIRA THERAPEUTICS INC (US) | 2017-07-26 | — | — | EP | disclosed |