SCHEMBL1917141

SCHEMBL1917141

O=C(O)CC(CC1CCOCC1)C(=O)N(c1nc(-c2ccccc2-c2ccc(N3CCCCC3=O)nc2)cs1)C1CC1

nearest known ligand 0.67

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
FFAR2 O15552 11/20 0.67
CNR2 P34972 1/20 0.35
BRS3 P32247 1/20 0.31
SLC12A5 Q9H2X9 2/20 0.31
GUCY1B2 O75343 2/20 0.31
GUCY1A2 P33402 2/20 0.31
GUCY1A1 Q02108 2/20 0.31
GUCY1B1 Q02153 2/20 0.31
GCK P35557 1/20 0.30
GSTO1 P78417 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1917136 1.00 FFAR2 (0.67) FFAR2CNR2BRS3SLC12A5GUCY1B2
SCHEMBL2397473 0.98 FFAR2 (0.67) FFAR2CNR2BRS3SLC12A5GCK
SCHEMBL1916323 0.98 FFAR2 (0.67) FFAR2CNR2BRS3SLC12A5GCK
SCHEMBL1915975 0.95 FFAR2 (0.74) FFAR2CNR2SLC12A5
SCHEMBL1915979 0.95 FFAR2 (0.74) FFAR2CNR2SLC12A5
SCHEMBL16498011 0.93 FFAR2 (0.73) FFAR2CNR2SLC12A5
SCHEMBL1916204 0.93 FFAR2 (0.75) FFAR2CNR2SLC12A5
SCHEMBL1917149 0.93 FFAR2 (0.75) FFAR2CNR2SLC12A5
SCHEMBL16498009 0.93 FFAR2 (0.73) FFAR2CNR2SLC12A5
SCHEMBL2398865 0.92 FFAR2 (0.57) FFAR2CNR2GCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110230477-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS EUROSCREEN S.A. (BE) 2011-09-22 US claimed
WO-2011076734-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING INFLAMMATORY DISEASES EUROSCREEN S.A. (BE) 2011-06-30 WO claimed
WO-2011076732-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING GASTROINTESTINAL DISORDERS EUROSCREEN S.A. (BE) 2011-06-30 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110230477-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS CPT1A, LIPC, PC FFAR2 295/4885CNR2 822/4885BRS3 1228/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.