Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | APAF1 | O14727 | 1/20 | 0.31 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | CCR8 | P51685 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL192091 | 0.86 | TSHR (0.38) | HTR2AHTR2CHTR2BTSHR | |
| SCHEMBL14000523 | 0.86 | ALDH1A1 (0.33) | HTR2AHTR2CHTR2BSMN1; SMN2LMNA | |
| SCHEMBL5124109 | 0.85 | TP53 (0.32) | HTR2AHTR2CHTR2BLMNA | |
| SCHEMBL4061438 | 0.83 | ALDH1A1 (0.36) | SMN1; SMN2LMNATSHRHTTALDH1A1 | |
| SCHEMBL4061433 | 0.83 | ALDH1A1 (0.36) | SMN1; SMN2LMNATSHRHTTALDH1A1 | |
| SCHEMBL10734696 | 0.81 | ALDH1A1 (0.40) | SMN1; SMN2LMNATSHRHTTALDH1A1 | |
| SCHEMBL843383 | 0.80 | ALDH1A1 (0.32) | SMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL4056836 | 0.78 | TLR7 (0.40) | HTR2AHTR2CHTR2BSMN1; SMN2LMNA | |
| SCHEMBL191697 | 0.76 | LMNA (0.39) | HTR2AHTR2CHTR2BSMN1; SMN2LMNA | |
| SCHEMBL1456954 | 0.71 | NPC1 (0.35) | SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8436176-B2 | Process for preparing 2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine | MEDICIS PHARMACEUTICAL CORPORATION (US) | 2013-05-07 | — | — | US | claimed |
| EP-1833827-B9 | PROCESS FOR PREPARING 2-METHYL-1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C][1,5]NAPHTHYRIDIN-4-AMINE | MEDA AB (SE) | 2012-01-04 | — | — | EP | claimed |
| EP-1833827-B1 | PROCESS FOR PREPARING 2-METHYL-1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C][1,5]NAPHTHYRIDIN-4-AMINE | MEDA AB (SE) | 2011-05-25 | — | — | EP | claimed |
| US-20080306266-A1 | Process for Preparing 2-Methyl-1-(2-Methylpropyl)-1H-Imidazo[4,5-C][1,5]Naphthyridin-4-Amine | 3M INNOVATIVE PROPERTIES COMPANY | 2008-12-11 | — | — | US | claimed |
| EP-1833827-A2 | PROCESS FOR PREPARING 2-METHYL-1-(2-METHYLPROPYL)-1H-IMIDAZOÝ4,5-C¨Ý1,5¨NAPHTHYRIDIN-4-AMINE | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2007-09-19 | — | — | EP | claimed |
| WO-2006074046-A2 | PROCESS FOR PREPARING 2-METHYL-1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C][1,5]NAPHTHYRIDIN-4-AMINE | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2006-07-13 | — | — | WO | claimed |
| US-8436176-B2 | Process for preparing 2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine | MEDICIS PHARMACEUTICAL CORPORATION (US) | 2013-05-07 | — | — | US | disclosed |
| EP-1833827-B9 | PROCESS FOR PREPARING 2-METHYL-1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C][1,5]NAPHTHYRIDIN-4-AMINE | MEDA AB (SE) | 2012-01-04 | — | — | EP | disclosed |
| EP-1833827-B1 | PROCESS FOR PREPARING 2-METHYL-1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C][1,5]NAPHTHYRIDIN-4-AMINE | MEDA AB (SE) | 2011-05-25 | — | — | EP | disclosed |
| US-20090240055-A1 | Method for 1H-Imidazo[4,5-C] Pyridines and Analogs Thereof | KREPSKI LARRY R | 2009-09-24 | — | — | US | disclosed |
| US-20080306266-A1 | Process for Preparing 2-Methyl-1-(2-Methylpropyl)-1H-Imidazo[4,5-C][1,5]Naphthyridin-4-Amine | 3M INNOVATIVE PROPERTIES COMPANY | 2008-12-11 | — | — | US | disclosed |
| EP-1937683-A1 | METHOD FOR 1H-IMIDAZOÝ4,5-c¨PYRIDINES AND ANALOGS THEREOF | Coley Pharmaceutical Group, Inc. (US) | 2008-07-02 | — | — | EP | disclosed |
| EP-1833827-A2 | PROCESS FOR PREPARING 2-METHYL-1-(2-METHYLPROPYL)-1H-IMIDAZOÝ4,5-C¨Ý1,5¨NAPHTHYRIDIN-4-AMINE | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2007-09-19 | — | — | EP | disclosed |
| WO-2007035935-A1 | METHOD FOR 1H-IMIDAZO[4,5-c]PYRIDINES AND ANALOGS THEREOF | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2007-03-29 | — | — | WO | disclosed |
| WO-2006074046-A2 | PROCESS FOR PREPARING 2-METHYL-1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C][1,5]NAPHTHYRIDIN-4-AMINE | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2006-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090240055-A1 | Method for 1H-Imidazo[4,5-C] Pyridines and Analogs Thereof | CYP4B1, CYP4F8, CYP4X1 | HTR2A 3613/4885HTR2C 1979/4885HTR2B 2513/4885 |
| US-20080306266-A1 | Process for Preparing 2-Methyl-1-(2-Methylpropyl)-1H-Imidazo[4,5-C][1,5]Naphthyridin-4-Amine | DNMT1, NT5C, JMJD1C | HTR2A 322/4885HTR2C 51/4885HTR2B 372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.