Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.39 |
| ▸ | CPT1A | P50416 | 1/20 | 0.38 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.38 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 2/20 | 0.37 |
| ▸ | FLT4 | P35916 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17078007 | 0.86 | ELANE (0.38) | NR4A2ALDH1A1TSHRL3MBTL1KMT2A | |
| SCHEMBL19181393 | 0.83 | CA1 (0.50) | KDM4EMCOLN3ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL28060100 | 0.83 | KDM4E (0.63) | ABL1KDM4EGPR27MCOLN3ALDH1A1 | |
| SCHEMBL17078013 | 0.76 | IDH1 (0.53) | ABL1GRIK1FLT1FLT4KDR | |
| SCHEMBL8627703 | 0.74 | ABL1 (0.48) | ABL1KDM4EPOLBMCOLN3FLT1 | |
| SCHEMBL19194087 | 0.73 | KDM4E (0.59) | ABL1KDM4EGPR27MCOLN3ALDH1A1 | |
| SCHEMBL5452555 | 0.72 | ABL1 (0.58) | ABL1KDM4EPOLBMCOLN3FLT1 | |
| SCHEMBL6542414 | 0.72 | CA1 (0.49) | ABL1KDM4EGPR27MCOLN3L3MBTL1 | |
| SCHEMBL21962924 | 0.71 | CA2 (0.61) | ABL1KDM4EFLT1FLT4KDR | |
| SCHEMBL5332370 | 0.71 | ABL1 (0.57) | ABL1KDM4EPOLBMCOLN3FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240092802-A1 | MU-OPIOID RECEPTOR AGONISTS AND USES THEREFOR | KURES, INC. | 2024-03-21 | — | — | US | disclosed |
| EP-3116509-B1 | A NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | UNIV COLUMBIA (US) | 2022-06-22 | — | — | EP | disclosed |
| EP-3116509-B1 | A NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | UNIV COLUMBIA (US) | 2022-06-22 | — | — | EP | disclosed |
| US-20220106279-A1 | CLASS OF MU-OPIOID RECEPTOR AGONISTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2022-04-07 | — | — | US | disclosed |
| US-20220106279-A1 | CLASS OF MU-OPIOID RECEPTOR AGONISTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2022-04-07 | — | — | US | disclosed |
| US-20190084949-A1 | NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-03-21 | — | — | US | disclosed |
| US-20190084949-A1 | NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-03-21 | — | — | US | disclosed |
| US-10183919-B2 | Class of mu-opioid receptor agonists | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-01-22 | — | — | US | disclosed |
| US-10183919-B2 | Class of mu-opioid receptor agonists | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-01-22 | — | — | US | disclosed |
| US-20170217913-A1 | A NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-08-03 | — | — | US | disclosed |
| US-20170217913-A1 | A NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-08-03 | — | — | US | disclosed |
| US-20170217913-A1 | A NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240092802-A1 | MU-OPIOID RECEPTOR AGONISTS AND USES THEREFOR | OPRL1, OPRM1, CDKL5 | ABL1 2330/4885KDM4E 812/4885GRIK1 145/4885 |
| US-10183919-B2 | Class of mu-opioid receptor agonists | OPRM1, OPRL1, OPRK1 | ABL1 1417/4885KDM4E 2011/4885GRIK1 476/4885 |
| US-20220106279-A1 | CLASS OF MU-OPIOID RECEPTOR AGONISTS | OPRM1, OPRL1, OPRK1 | ABL1 1417/4885KDM4E 2011/4885GRIK1 476/4885 |
| US-20190084949-A1 | NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | OPRM1, OPRL1, OPRK1 | ABL1 1602/4885KDM4E 2088/4885GRIK1 415/4885 |
| US-20170217913-A1 | A NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | OPRM1, OPRL1, OPRK1 | ABL1 1653/4885KDM4E 2093/4885GRIK1 433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.