Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | MLYCD | O95822 | 2/20 | 0.45 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11983688 | 0.93 | HPGD (0.57) | HPGDLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL12237841 | 0.85 | CDK4 (0.50) | LMNASMN1; SMN2ALDH1A1CES2CES1 | |
| SCHEMBL31295694 | 0.83 | OPRD1 (0.46) | HPGDMEN1KMT2AOPRD1ALDH1A1 | |
| SCHEMBL7967022 | 0.82 | MLYCD (0.64) | HPGDLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL15071548 | 0.82 | HPGD (0.59) | HPGDMEN1KMT2AOPRD1ALDH1A1 | |
| SCHEMBL7456186 | 0.82 | ALDH1A1 (0.46) | HPGDLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL121475 | 0.82 | HPGD (0.66) | HPGDLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL17817832 | 0.79 | NTRK2 (0.49) | HPGDLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL10455765 | 0.79 | EGFR (0.62) | HPGDLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL9888697 | 0.78 | MLYCD (0.57) | SMN1; SMN2MEN1KMT2AOPRD1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794595-B1 | HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF | BOEHRINGER INGELHEIM INT (DE) | 2017-08-02 | — | — | EP | disclosed |