Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | ESR1 | P03372 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | TDO2 | P48775 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28239839 | 0.78 | MEN1 (0.55) | KMT2AMEN1ESR1GAAESR2 | |
| SCHEMBL2461728 | 0.78 | CA2 (0.36) | KMT2AMEN1ESR1GAAESR2 | |
| SCHEMBL1360782 | 0.76 | MEN1 (0.39) | KMT2AMEN1GAAALDH1A1MAPT | |
| SCHEMBL2516102 | 0.75 | LMNA (0.56) | KMT2AMEN1ESR1GAAESR2 | |
| SCHEMBL2461723 | 0.75 | LMNA (0.34) | LMNACA1CA2CA9TRPA1 | |
| SCHEMBL20746493 | 0.73 | TRPA1 (0.45) | KMT2AMEN1KDM4EALDH1A1F2 | |
| SCHEMBL29284823 | 0.71 | ALDH1A1 (0.56) | KMT2AMEN1ESR1GAAESR2 | |
| SCHEMBL19125575 | 0.71 | KMT2A (0.50) | KMT2AMEN1ESR1GAAESR2 | |
| SCHEMBL28134701 | 0.70 | LMNA (0.45) | KMT2AMEN1ESR1ESR2PTGS2 | |
| SCHEMBL17448355 | 0.70 | CA2 (0.41) | KMT2AMEN1GAAPTGS2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365974-B1 | FLUORINATED BENZOTHIAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND IMAGING AGENT FOR DIAGNOSING ALTZHEIMER'S DISEASE USING THE SAME | SNU R&DB FOUNDATION (KR) | 2013-12-25 | — | — | EP | claimed |
| US-20110250136-A1 | FLUORINATED BENZOTHIAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND IMAGING AGENT FOR DIAGNOSING ALTZHEIMER'S DISEASE USING THE SAME | SNU R&DB FOUNDATION (KR) | 2011-10-13 | — | — | US | claimed |
| EP-2365974-A1 | FLUORINATED BENZOTHIAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND IMAGING AGENT FOR DIAGNOSING ALTZHEIMER'S DISEASE USING THE SAME | SNU R&DB Foundation (KR) | 2011-09-21 | — | — | EP | claimed |
| WO-2010053218-A1 | FLUORINATED BENZOTHIAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND IMAGING AGENT FOR DIAGNOSING ALTZHEIMER'S DISEASE USING THE SAME | SNU R&DB FOUNDATION (KR) | 2010-05-14 | — | — | WO | claimed |
| WO-2009049837-A1 | PROCESS FOR PREPARING 8-HYDRAZINO-8-ARYLOCTANOYL DERIVATIVES AND THEIR USE | REUTER CHEMISCHER APPARATEBAU KG (DE) | 2009-04-23 | — | — | WO | claimed |
| US-5073643-A | High yield synthesis of hydroxyl-containing cationic photoinitiators | POLYSET CORPORATION (US) | 1991-12-17 | — | — | US | claimed |
| US-9850218-B2 | Thiazole compounds, compositions and methods for treatment of degenerative diseases and disorders | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2017-12-26 | — | — | US | disclosed |
| US-20160130241-A1 | THIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS | MUSC Foundation for Research Development (10 pp.) | 2016-05-12 | — | — | US | disclosed |
| US-9073942-B2 | Antiviral compounds with a heterotricycle moiety | LUPIN LIMITED (IN) | 2015-07-07 | — | — | US | disclosed |
| US-20150010504-A1 | Antiviral Compounds with a Heterotricycle Moiety | LUPIN LIMITED (IN) | 2015-01-08 | — | — | US | disclosed |
| EP-2812327-A1 | ANTIVIRAL COMPOUNDS WITH A HETEROTRICYCLE MOIETY | Lupin Limited (IN) | 2014-12-17 | — | — | EP | disclosed |
| US-20140275178-A1 | THIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2014-09-18 | — | — | US | disclosed |
| EP-2341054-B1 | Process for the synthesis of HMG-CoA reductase inhibitors | LEK PHARMACEUTICALS (SI) | 2014-06-25 | — | — | EP | disclosed |
| EP-0618907-A1 | 1-(ARYLALKYL-AMINOALKYL)IMIDAZOLE DERIVATIVES, PROCESSES OF PREPARATION AND USE AS THERAPEUTICAL AGENTS | Knoll AG (DE) | 1994-10-12 | — | — | EP | disclosed |
| US-5340898-A | A mixtures comprising an ionic onium borate photoinitiators; nontoxic | RHONE-POULENC CHIMIE (FR) | 1994-08-23 | — | — | US | disclosed |
| WO-1994005617-A1 | SYNTHESIS OF HALOENONES AND ARYL OR ALKYL SUBSTITUTED ENONES OR ALKENES | NEW YORK UNIVERSITY (US) | 1994-03-17 | — | — | WO | disclosed |
| US-5079378-A | Cationic polymerization, inproved solubility | POLYSET CORPORATION (US) | 1992-01-07 | — | — | US | disclosed |
| EP-0210589-B1 | PROCESS FOR PREPARING OPTICALLY ACTIVE ALPHA-HALOGEN KETALS | ZAMBON S.p.A. (IT) | 1990-09-26 | — | — | EP | disclosed |
| US-4861903-A | Intermediates for preparing optically active carboxylic acids | ZAMBON SPA (IT) | 1989-08-29 | — | — | US | disclosed |
| EP-0210589-A2 | Process for preparing optically active alpha-halogen ketals | ZAMBON S.p.A. (IT) | 1987-02-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110250136-A1 | FLUORINATED BENZOTHIAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND IMAGING AGENT FOR DIAGNOSING ALTZHEIMER'S DISEASE USING THE SAME | APBA1, APP, PSEN1 | KMT2A 3742/4885MEN1 2352/4885ESR1 2326/4885 |
| US-20140275178-A1 | THIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS | TTR, PPARG, PPARD | KMT2A 4254/4885MEN1 1314/4885ESR1 1788/4885 |
| US-20150010504-A1 | Antiviral Compounds with a Heterotricycle Moiety | HCCS, UQCRB, HAVCR2 | KMT2A 4564/4885MEN1 2743/4885ESR1 3548/4885 |
| US-20160130241-A1 | THIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS | TTR, PPARG, PPARD | KMT2A 4254/4885MEN1 1314/4885ESR1 1788/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.