⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385324 | 0.85 | — | — | |
| SCHEMBL4643767 | 0.85 | — | — | |
| SCHEMBL2942968 | 0.83 | SIGMAR1 (0.35) | — | |
| SCHEMBL9321327 | 0.77 | ALOX15 (0.47) | — | |
| SCHEMBL4721663 | 0.77 | — | — | |
| SCHEMBL4992871 | 0.77 | — | — | |
| SCHEMBL2943510 | 0.77 | — | — | |
| SCHEMBL1193464 | 0.77 | — | — | |
| SCHEMBL15047584 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL4802743 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1986645-B1 | GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC (US) | 2012-01-04 | — | — | EP | disclosed |
| EP-1986645-A1 | GLUCOKINASE ACTIVATORS | Array Biopharma, Inc. (US) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007089512-A1 | GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC. (US) | 2007-08-09 | — | — | WO | disclosed |
| US-7038061-B2 | Crystalline anhydrous and monohydrate benzoate salts of (2′S,3S)-3-hydroxy-N-(2-[N-methyl-N-4-(N-propylamino-carbonyl)phenyl]amino-2-phenyl)-ethylpyrrolidine | PFIZER INC (US) | 2006-05-02 | — | — | US | disclosed |
| US-20040235936-A1 | Crystalline anhydrous and monohydrate benzoate salts of (2'S,3S)-3-hydroxy-N-{2-[N-methyl-N-4-(N-propylamino-carbonyl)phenyl]amino-2-phenyl}-ethylpyrrolidine | PFIZER INC. | 2004-11-25 | — | — | US | disclosed |
| EP-1478622-A1 | CRYSTALLINE ANHYDROUS AND MONOHYDRATE BENZOATE SALTS OF (2'S,3S)-3-HYDROXY-N- 2 N-METHYL-N-4-(N-PROPYLAMINO-CARBONYL)PHENYL]AMINO-2-PHENYL -ETHYLPYRROLIDINE | Pfizer Products Inc. (US) | 2004-11-24 | — | — | EP | disclosed |
| EP-0934264-B1 | PYRROLIDINYL AND PYRROLINYL ETHYLAMINE COMPOUNDS AS KAPPA AGONISTS | PFIZER (US) | 2003-09-10 | — | — | EP | disclosed |
| WO-2003072544-A1 | CRYSTALLINE ANHYDROUS AND MONOHYDRATE BENZOATE SALTS OF (2'S,3S)-3-HYDROXY-N-{2{N-METHYL-N-4-(N-PROPYLAMINO-CARBONYL)PHENYL]AMINO-2-PHENYL}-ETHYLPYRROLIDINE | PFIZER PRODUCTS INC. (US) | 2003-09-04 | — | — | WO | disclosed |
| US-6313302-B2 | OPIOID KAPPA RECEPTOR ANTAGONISTS; SIDE EFFECT REDUCTION; ANALGESICS, ANTIINFLAMMATORY AGENTS, ANESTHETICS, AND NEUROPROTECTANTS | PFIZER INC. | 2001-11-06 | — | — | US | disclosed |
| US-6313302-B2 | OPIOID KAPPA RECEPTOR ANTAGONISTS; SIDE EFFECT REDUCTION; ANALGESICS, ANTIINFLAMMATORY AGENTS, ANESTHETICS, AND NEUROPROTECTANTS | PFIZER INC. | 2001-11-06 | — | — | US | disclosed |
| US-20010009921-A1 | Less tendency to cause drug dependency, analgesic, anesthetic, anti-inflammatory or neuroprotective agent; subtype of opoid receptor | ITO FUMITAKA (JP) | 2001-07-26 | — | — | US | disclosed |
| US-20010009921-A1 | Less tendency to cause drug dependency, analgesic, anesthetic, anti-inflammatory or neuroprotective agent; subtype of opoid receptor | ITO FUMITAKA (JP) | 2001-07-26 | — | — | US | disclosed |
| US-20010008890-A1 | Useful as analgesic, anesthetic, antiinflammatory or neuroprotective agents and in treatment of arthritis, stroke, bowel disease | ITO FUMITAKA (JP) | 2001-07-19 | — | — | US | disclosed |
| US-20010008890-A1 | Useful as analgesic, anesthetic, antiinflammatory or neuroprotective agents and in treatment of arthritis, stroke, bowel disease | ITO FUMITAKA (JP) | 2001-07-19 | — | — | US | disclosed |
| US-6201007-B1 | OPIOID KAPPA RECEPTOR AGONISTS; ANALGESICS, ANESTHETICS, NEUROPROTECTIVE AND ANTIINFLAMMATORY AGENTS; STROKES, GASTROINTESTINAL DISORDERS | PFIZER INC. | 2001-03-13 | — | — | US | disclosed |
| US-6201007-B1 | OPIOID KAPPA RECEPTOR AGONISTS; ANALGESICS, ANESTHETICS, NEUROPROTECTIVE AND ANTIINFLAMMATORY AGENTS; STROKES, GASTROINTESTINAL DISORDERS | PFIZER INC. | 2001-03-13 | — | — | US | disclosed |
| CN-1237962-A | Pyrrolidinyl and pyrrolinyl ethylamine compounds as K agonists | PFIZER (US) | 1999-12-08 | — | — | CN | disclosed |
| CN-1237962-A | Pyrrolidinyl and pyrrolinyl ethylamine compounds as K agonists | PFIZER (US) | 1999-12-08 | — | — | CN | disclosed |
| EP-0934264-A1 | PYRROLIDINYL AND PYRROLINYL ETHYLAMINE COMPOUNDS AS KAPPA AGONISTS | PFIZER INC. (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998012177-A1 | PYRROLIDINYL AND PYRROLINYL ETHYLAMINE COMPOUNDS AS KAPPA AGONISTS | PFIZER INC. (JP) | 1998-03-26 | — | — | WO | disclosed |