Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 17/20 | 1.00 |
| ▸ | PGR | P06401 | 4/20 | 0.75 |
| ▸ | AR | P10275 | 4/20 | 0.75 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.75 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.75 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.75 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.66 |
| ▸ | CNR1 | P21554 | 1/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19201574 | 0.93 | NR3C1 (1.00) | NR3C1PGRARADORA3NR3C2 | |
| SCHEMBL19201610 | 0.92 | NR3C1 (1.00) | NR3C1PGRARADORA3NR3C2 | |
| SCHEMBL19201589 | 0.91 | NR3C1 (1.00) | NR3C1PGRARADORA3NR3C2 | |
| SCHEMBL19201306 | 0.91 | NR3C1 (1.00) | NR3C1PGRARADORA3NR3C2 | |
| SCHEMBL26964859 | 0.91 | NR3C1 (1.00) | NR3C1PGRARADORA3NR3C2 | |
| SCHEMBL19201588 | 0.91 | NR3C1 (1.00) | NR3C1PGRARADORA3NR3C2 | |
| SCHEMBL19201570 | 0.88 | NR3C1 (1.00) | NR3C1PGRARADORA3NR3C2 | |
| SCHEMBL13950976 | 0.88 | NR3C1 (0.86) | NR3C1PGRARADORA3NR3C2 | |
| SCHEMBL14421353 | 0.88 | NR3C1 (0.86) | NR3C1PGRARADORA3NR3C2 | |
| SCHEMBL13951204 | 0.88 | NR3C1 (0.88) | NR3C1PGRARADORA3NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3407916-B1 | PHOSPHONATE LINKERS AND THEIR USE TO FACILITATE CELLULAR RETENTION OF COMPOUNDS | MERCK SHARP & DOHME LLC (US) | 2023-12-20 | — | — | EP | disclosed |
| US-20230147502-A1 | PHOSPHONATE LINKERS AND THEIR USE TO FACILIATE CELLULAR RETENTION OF COMPOUNDS | MERCK SHARP & DOHME LLC (US) | 2023-05-11 | — | — | US | disclosed |
| US-20230147502-A1 | PHOSPHONATE LINKERS AND THEIR USE TO FACILIATE CELLULAR RETENTION OF COMPOUNDS | MERCK SHARP & DOHME LLC (US) | 2023-05-11 | — | — | US | disclosed |
| US-20210015930-A1 | PHOSPHONATE LINKERS AND THEIR USE TO FACILITATE CELLULAR RETENTION OF COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2021-01-21 | — | — | US | disclosed |
| US-10869929-B2 | Phosphonate linkers and their use to facilitate cellular retention of compounds | MERCK SHARP & DOHME CORP. (US) | 2020-12-22 | — | — | US | disclosed |
| US-20190030171-A1 | PHOSPONATE LINKERS AND THEIR USE TO FACILITATE CELLULAR RETENTION OF COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2019-01-31 | — | — | US | disclosed |
| WO-2017132103-A2 | PHOSPHONATE LINKERS AND THEIR USE TO FACILITATE CELLULAR RETENTION OF COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2017-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230147502-A1 | PHOSPHONATE LINKERS AND THEIR USE TO FACILIATE CELLULAR RETENTION OF COMPOUNDS | PHOSPHO1, SLC46A1, SLC19A1 | NR3C1 4524/4885PGR 2847/4885AR 3290/4885 |
| US-20190030171-A1 | PHOSPONATE LINKERS AND THEIR USE TO FACILITATE CELLULAR RETENTION OF COMPOUNDS | PHOSPHO1, PHPT1, PSPH | NR3C1 4471/4885PGR 2322/4885AR 3146/4885 |
| US-20210015930-A1 | PHOSPHONATE LINKERS AND THEIR USE TO FACILITATE CELLULAR RETENTION OF COMPOUNDS | PHOSPHO1, TK1, MSN | NR3C1 4614/4885PGR 2980/4885AR 3602/4885 |
| US-10869929-B2 | Phosphonate linkers and their use to facilitate cellular retention of compounds | PHOSPHO1, TK1, MSN | NR3C1 4614/4885PGR 2980/4885AR 3602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.