Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 1/20 | 0.48 |
| ▸ | PGK2 | P07205 | 1/20 | 0.48 |
| ▸ | TYMS | P04818 | 1/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.37 |
| ▸ | ENO1 | P06733 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
| ▸ | OTC | P00480 | 1/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13266984 | 0.79 | MEN1 (0.56) | PGK1PGK2LPAR1S1PR2S1PR4 | |
| SCHEMBL1156656 | 0.76 | ALDH1A1 (0.41) | ALDH1A1 | |
| SCHEMBL6908706 | 0.76 | ALDH1A1 (0.46) | PGK1PGK2LPAR1ALDH1A1GRIN2D | |
| SCHEMBL10285862 | 0.76 | CASP2 (0.53) | PGK1PGK2LPAR1S1PR2S1PR4 | |
| SCHEMBL19988193 | 0.75 | PGK1 (0.52) | PGK1PGK2TYMSALDH1A1CA12 | |
| SCHEMBL1387175 | 0.75 | — | — | |
| SCHEMBL10250795 | 0.74 | PGK1 (0.47) | PGK1PGK2LPAR1ENO1ALDH1A1 | |
| SCHEMBL9543384 | 0.73 | PGK1 (0.50) | PGK1PGK2TYMSALDH1A1S1PR2 | |
| SCHEMBL23471139 | 0.71 | MEN1 (0.46) | LPAR1ALDH1A1 | |
| SCHEMBL28749551 | 0.71 | PGK1 (0.48) | PGK1PGK2TYMSALDH1A1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230147502-A1 | PHOSPHONATE LINKERS AND THEIR USE TO FACILIATE CELLULAR RETENTION OF COMPOUNDS | MERCK SHARP & DOHME LLC (US) | 2023-05-11 | — | — | US | disclosed |
| WO-2017132103-A2 | PHOSPHONATE LINKERS AND THEIR USE TO FACILITATE CELLULAR RETENTION OF COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2017-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230147502-A1 | PHOSPHONATE LINKERS AND THEIR USE TO FACILIATE CELLULAR RETENTION OF COMPOUNDS | PHOSPHO1, SLC46A1, SLC19A1 | PGK1 251/4885PGK2 245/4885TYMS 155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.