Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | PARP1 | P09874 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.57 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | CD38 | P28907 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | GBA1 | P04062 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21532932 | 0.90 | NPC1 (0.71) | MAPTGAAPARP1NPC1RAB9A | |
| SCHEMBL21532953 | 0.87 | RAB9A (0.56) | MAPTGAAPARP1NPC1RAB9A | |
| SCHEMBL21532931 | 0.85 | RAB9A (0.57) | MAPTGAAPARP1NPC1RAB9A | |
| SCHEMBL21532952 | 0.85 | NPC1 (0.55) | MAPTGAAPARP1NPC1RAB9A | |
| SCHEMBL19206634 | 0.84 | NR1H4 (0.57) | MAPTGAAPARP1NPC1RAB9A | |
| SCHEMBL19240119 | 0.83 | PNLIP (0.54) | MAPTGAAPARP1NPC1RAB9A | |
| SCHEMBL19206631 | 0.82 | PARP1 (0.59) | MAPTGAAPARP1NPC1RAB9A | |
| SCHEMBL1035548 | 0.81 | PARP1 (0.65) | MAPTPARP1NPC1RAB9ACASP3 | |
| SCHEMBL19206639 | 0.80 | PARP1 (0.56) | MAPTGAAPARP1NPC1RAB9A | |
| SCHEMBL27772010 | 0.79 | PARP1 (0.72) | MAPTGAAPARP1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10383868-B2 | Quinoline containing compounds and their use for treating endoplasmic reticulum stress-related diseases | NEURODON CORPORATION | 2019-08-20 | — | — | US | disclosed |
| US-20170231973-A1 | QUINOLINE CONTAINING COMPOUNDS AND THEIR USE FOR TREATING ENDOPLASMIC RETICULUM STRESS-RELATED DISEASES | NEURODON CORPORATION | 2017-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170231973-A1 | QUINOLINE CONTAINING COMPOUNDS AND THEIR USE FOR TREATING ENDOPLASMIC RETICULUM STRESS-RELATED DISEASES | ATP2A1, ATP2A3, ATP2A2 | MAPT 1112/4885GAA 46/4885PARP1 2403/4885 |
| US-10383868-B2 | Quinoline containing compounds and their use for treating endoplasmic reticulum stress-related diseases | ATP2A1, ATP2A3, ATP2A2 | MAPT 1112/4885GAA 46/4885PARP1 2403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.