Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 5/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.39 |
| ▸ | MDM4 | O15151 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | OXTR | P30559 | 3/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1920824 | 0.97 | KMT2A (0.43) | KMT2AMAPTHTTNPSR1ALDH1A1 | |
| SCHEMBL1920825 | 0.97 | KMT2A (0.45) | KMT2AMAPTHTTNPSR1ALDH1A1 | |
| SCHEMBL1920797 | 0.93 | ALDH1A1 (0.42) | KMT2AMAPTHTTNPSR1ALDH1A1 | |
| SCHEMBL1920366 | 0.93 | MDM4 (0.42) | KMT2AMAPTHTTNPSR1ALDH1A1 | |
| SCHEMBL1920350 | 0.91 | MAPT (0.43) | KMT2AMAPTHTTNPSR1ALDH1A1 | |
| SCHEMBL1920294 | 0.89 | MDM4 (0.48) | KMT2AMAPTHTTNPSR1ALDH1A1 | |
| SCHEMBL1920177 | 0.88 | HTT (0.44) | KMT2AMAPTHTTNPSR1ALDH1A1 | |
| SCHEMBL1919930 | 0.88 | MDM4 (0.39) | KMT2AMAPTHTTNPSR1ALDH1A1 | |
| SCHEMBL1920870 | 0.88 | OXTR (0.46) | KMT2AMAPTHTTNPSR1ALDH1A1 | |
| SCHEMBL1630074 | 0.87 | MAPT (0.49) | KMT2AMAPTHTTNPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245006-B1 | SULFONAMIDES AS OREXIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2011-06-01 | — | — | EP | disclosed |