Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | OXTR | P30559 | 3/20 | 0.43 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MDM4 | O15151 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1920366 | 0.97 | MDM4 (0.42) | MAPTKEAP1NFE2L2NPSR1ALDH1A1 | |
| SCHEMBL1920870 | 0.96 | OXTR (0.46) | MAPTKEAP1NFE2L2NPSR1ALDH1A1 | |
| SCHEMBL1920294 | 0.94 | MDM4 (0.48) | MAPTKEAP1NFE2L2NPSR1ALDH1A1 | |
| SCHEMBL1920212 | 0.93 | CRHBP (0.44) | MAPTKEAP1NFE2L2NPSR1ALDH1A1 | |
| SCHEMBL1919930 | 0.93 | MDM4 (0.39) | MAPTKEAP1NFE2L2NPSR1ALDH1A1 | |
| SCHEMBL1920824 | 0.92 | KMT2A (0.43) | MAPTKEAP1NFE2L2NPSR1ALDH1A1 | |
| SCHEMBL1920825 | 0.92 | KMT2A (0.45) | MAPTKEAP1NFE2L2NPSR1ALDH1A1 | |
| SCHEMBL1920685 | 0.91 | KMT2A (0.41) | MAPTKEAP1NFE2L2NPSR1ALDH1A1 | |
| SCHEMBL1919944 | 0.91 | CRHBP (0.47) | MAPTKEAP1NFE2L2NPSR1ALDH1A1 | |
| SCHEMBL1920797 | 0.88 | ALDH1A1 (0.42) | MAPTKEAP1NFE2L2NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245006-B1 | SULFONAMIDES AS OREXIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2011-06-01 | — | — | EP | disclosed |