Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | GLS | O94925 | 1/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8722201 | 0.82 | SMN1; SMN2 (0.69) | SMN1; SMN2RAB9AKMT2AMAPK1KDM4E | |
| SCHEMBL4288847 | 0.79 | MMP13 (0.58) | SMN1; SMN2KMT2AHPGDALDH1A1 | |
| SCHEMBL20610606 | 0.76 | HPGD (0.60) | SMN1; SMN2RAB9AKMT2AMAPK1KDM4E | |
| SCHEMBL4174785 | 0.75 | SMN1; SMN2 (0.59) | SMN1; SMN2RAB9AKMT2AMAPK1KDM4E | |
| SCHEMBL166484 | 0.75 | LMNA (0.82) | SMN1; SMN2RAB9AKMT2AKDM4EHSD17B10 | |
| SCHEMBL22600769 | 0.75 | ALDH1A1 (0.48) | RAB9AHPGDALDH1A1POLBNPC1 | |
| SCHEMBL1198985 | 0.75 | NPC1 (0.58) | SMN1; SMN2RAB9AKMT2AKDM4EALDH1A1 | |
| SCHEMBL21065524 | 0.74 | SMN1; SMN2 (0.79) | SMN1; SMN2RAB9AKMT2AKDM4EALDH1A1 | |
| SCHEMBL29460273 | 0.74 | SMN1; SMN2 (0.79) | SMN1; SMN2RAB9AKMT2AKDM4EALDH1A1 | |
| SCHEMBL30522589 | 0.74 | SMN1; SMN2 (1.00) | SMN1; SMN2RAB9AKMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414239-A2 | INHIBITORS OF RECEPTOR-INTERACTING PROTEIN KINASE 1 | Denali Therapeutics Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |