Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.58 |
| ▸ | RAB9A | P51151 | 9/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | GRM5 | P41594 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | F2 | P00734 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3422874 | 0.83 | GRM4 (0.51) | NPC1RAB9ASMN1; SMN2KDM4EPKM | |
| SCHEMBL9384187 | 0.81 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2KDM4ETP53 | |
| SCHEMBL16517047 | 0.78 | PYGL (0.40) | NPC1RAB9ASMN1; SMN2PKMGRM5 | |
| SCHEMBL4192471 | 0.77 | L3MBTL1 (0.58) | NPC1RAB9ASMN1; SMN2KDM4ETP53 | |
| SCHEMBL4178487 | 0.77 | RAB9A (0.50) | NPC1RAB9ASMN1; SMN2KDM4ETP53 | |
| SCHEMBL19748 | 0.77 | KMT2A (0.61) | NPC1RAB9ASMN1; SMN2KDM4ETP53 | |
| SCHEMBL1735163 | 0.77 | ADORA2A (0.46) | NPC1RAB9ASMN1; SMN2KDM4ETP53 | |
| SCHEMBL5906988 | 0.76 | KDR (0.54) | NPC1RAB9ASMN1; SMN2KDM4EPKM | |
| SCHEMBL23212117 | 0.76 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL6003795 | 0.76 | RAB9A (0.58) | NPC1RAB9ASMN1; SMN2KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114516855-A | Preparation of pyridylpyrazole amide compounds and intermediates therefor | 湖南化工研究院有限公司 | 2022-05-20 | — | — | CN | claimed |
| EP-3141545-A1 | POLYSUBSTITUTED PYRIDYLPYRAZOLE AMIDE AND PREPARATION METHOD AND USE THEREOF | Zhaoqing Zhenge Biological Technology Co., Ltd. (CN) | 2017-03-15 | — | — | EP | claimed |
| EP-2295425-B1 | 1-SUBSTITUTED PYRIDYL-PYRAZOLYL AMIDE COMPOUND AND USES THEREOF | SHENYANG SCIENCREAT CHEMICALS CO LTD (CN) | 2016-09-07 | — | — | EP | claimed |
| US-20150322037-A1 | POLYSUBSTITUTED PYRIDYL PYRAZOLECARBOXAMIDE AND PREPARATION METHOD AND USE THEREOF | ZHAOQING ZHENGE BIOLOGICAL TECHNOLOGY CO., LTD | 2015-11-12 | — | — | US | claimed |
| EP-3941912-B1 | PESTICIDALLY ACTIVE AZOLE AMIDE COMPOUNDS | SYNGENTA CROP PROTECTION AG (CH) | 2023-12-13 | — | — | EP | disclosed |
| EP-3632911-B1 | METHOD FOR PREPARING ISOXAZINONE COMPOUND AND APPLICATION THEREOF | ZHEJIANG ZHUJI UNITED CHEMICALS CO LTD (CN) | 2023-08-09 | — | — | EP | disclosed |
| EP-4086255-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE IN PREVENTING OR TREATING BACTERIAL INFECTIONS | Mutabilis (FR) | 2022-11-09 | — | — | EP | disclosed |
| EP-3519411-B1 | HETEROCYCLIC COMPOUNDS AND THEIR USE IN PREVENTING OR TREATING BACTERIAL INFECTIONS | MUTABILIS (FR) | 2022-06-22 | — | — | EP | disclosed |
| EP-3519411-B1 | HETEROCYCLIC COMPOUNDS AND THEIR USE IN PREVENTING OR TREATING BACTERIAL INFECTIONS | MUTABILIS (FR) | 2022-06-22 | — | — | EP | disclosed |
| CN-114516855-A | Preparation of pyridylpyrazole amide compounds and intermediates therefor | 湖南化工研究院有限公司 | 2022-05-20 | — | — | CN | disclosed |
| CN-114516855-A | Preparation of pyridylpyrazole amide compounds and intermediates therefor | 湖南化工研究院有限公司 | 2022-05-20 | — | — | CN | disclosed |
| CN-113929680-A | Heterocyclic compounds and their use in the prevention or treatment of bacterial infections | 拜欧蒂姆公司 | 2022-01-14 | — | — | CN | disclosed |
| EP-2560966-A2 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | Verseon Corporation (US) | 2013-02-27 | — | — | EP | disclosed |
| US-20130040950-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | VERSEON CORPORATION (US) | 2013-02-14 | — | — | US | disclosed |
| WO-2012174362-A1 | PYRAZOLE DERIVATIVES AS CANNABINOID RECEPTOR 1 ANTAGONISTS | RESEARCH TRIANGLE INSTITUTE (US) | 2012-12-20 | — | — | WO | disclosed |
| WO-2011126903-A2 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | VERSEON, INC. (US) | 2011-10-13 | — | — | WO | disclosed |
| US-20110046186-A1 | 1-Substituted Pyridyl-Pyrazolyl Amide Compounds and Uses Thereof | SHENYANG SCIENCREAT CHEMICALS CO., LTD (CN) | 2011-02-24 | — | — | US | disclosed |
| US-20060183780-A1 | Pyrazole compounds useful in the treatment of inflammation | BIOLIPOX AB (SE) | 2006-08-17 | — | — | US | disclosed |
| EP-1603897-A1 | PYRAZOLE COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATION | Biolipox AB (SE) | 2005-12-14 | — | — | EP | disclosed |
| WO-2004080999-A1 | PYRAZOLE COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2004-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046186-A1 | 1-Substituted Pyridyl-Pyrazolyl Amide Compounds and Uses Thereof | AADAC, DDT, PIR | NPC1 2855/4885RAB9A 757/4885SMN1; SMN2 2690/4885 |
| US-20150322037-A1 | POLYSUBSTITUTED PYRIDYL PYRAZOLECARBOXAMIDE AND PREPARATION METHOD AND USE THEREOF | PFAS, CYP3A5, PNPO | NPC1 3484/4885RAB9A 1860/4885SMN1; SMN2 2679/4885 |
| US-20060183780-A1 | Pyrazole compounds useful in the treatment of inflammation | ALOX15, ALOX12, ALOX15B | NPC1 3112/4885RAB9A 3284/4885SMN1; SMN2 4299/4885 |
| US-20130040950-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | TFPI, PLAT, SERPINC1 | NPC1 3015/4885RAB9A 1958/4885SMN1; SMN2 3708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.