Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19212451 | 0.79 | GPR119 (0.47) | SMN1; SMN2HPGDLMNAALOX15USP2 | |
| SCHEMBL29707311 | 0.79 | GPR119 (0.47) | SMN1; SMN2HPGDLMNAALOX15USP2 | |
| SCHEMBL17422311 | 0.77 | KDM4E (0.37) | SMN1; SMN2MEN1KMT2AKDM4EHPGD | |
| SCHEMBL19212177 | 0.77 | KDM4E (0.41) | SMN1; SMN2MEN1KMT2AKDM4EHPGD | |
| SCHEMBL19212179 | 0.76 | ALDH1A1 (0.43) | SMN1; SMN2MEN1KMT2AKDM4EHPGD | |
| SCHEMBL11352178 | 0.76 | BTK (0.38) | SMN1; SMN2MEN1KMT2AKDM4EHPGD | |
| SCHEMBL28866522 | 0.74 | KDM4E (0.33) | SMN1; SMN2MEN1KMT2AKDM4EHPGD | |
| SCHEMBL29173633 | 0.73 | CA12 (0.47) | SMN1; SMN2MEN1KMT2AKDM4EHPGD | |
| SCHEMBL17422299 | 0.73 | ALDH1A1 (0.44) | SMN1; SMN2MEN1KMT2AKDM4ELMNA | |
| SCHEMBL28094905 | 0.72 | LMNA (0.43) | SMN1; SMN2KDM4ELMNAALOX15USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414252-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | Forma Therapeutics, Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017139778-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2017-08-17 | — | — | WO | disclosed |