Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4138974 | 0.83 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2GAAKDM4EALOX15 | |
| SCHEMBL17422311 | 0.81 | KDM4E (0.37) | ALDH1A1SMN1; SMN2GAAKDM4EALOX15 | |
| SCHEMBL11352178 | 0.80 | BTK (0.38) | ALDH1A1SMN1; SMN2GAAKDM4EALOX15 | |
| SCHEMBL23235276 | 0.79 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2GAAKDM4EHTT | |
| SCHEMBL4941863 | 0.79 | GPR119 (0.47) | ALDH1A1SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL18876516 | 0.78 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2KDM4EHTTFFAR4 | |
| SCHEMBL17422273 | 0.75 | POLB (0.44) | ALDH1A1GAALMNAL3MBTL1MEN1 | |
| SCHEMBL17422238 | 0.75 | DPP4 (0.40) | SMN1; SMN2KDM4EALOX15HTTFFAR4 | |
| SCHEMBL4944470 | 0.75 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2GAAKDM4ELMNA | |
| SCHEMBL6223415 | 0.75 | ALDH3A1 (0.53) | ALDH1A1SMN1; SMN2ALOX15LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230242541-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-08-03 | — | — | US | disclosed |
| EP-3386988-B1 | NOVEL DIHYDROPYRANOPYRIMIDINONE DERIVATIVES, AND USE THEREOF | ST PHARM CO LTD (KR) | 2021-09-15 | — | — | EP | disclosed |
| EP-3166945-B1 | NOVEL TRIAZOLOPYRIMIDINONE OR TRIAZOLOPYRIDINONE DERIVATIVES, AND USE THEREOF | ST PHARM CO LTD (KR) | 2019-10-09 | — | — | EP | disclosed |
| US-10336765-B2 | Dihydropyranopyrimidinone derivatives, and use thereof | ST. PHARM CO., LTD. (KR) | 2019-07-02 | — | — | US | disclosed |
| US-10179785-B2 | Imidazotriazinone or imidazopyrazinone derivatives, and use thereof | ST PHARM CO., LTD. (KR) | 2019-01-15 | — | — | US | disclosed |
| US-20180362538-A1 | Novel Dihydropyranopyrimidinone Derivatives, and Use Thereof | ST. PHARM CO., LTD. (KR) | 2018-12-20 | — | — | US | disclosed |
| US-9914737-B2 | Triazolopyrimidinone or triazolopyridinone derivatives, and use thereof | ST PHARM CO., LTD. (KR) | 2018-03-13 | — | — | US | disclosed |
| US-20170166572-A1 | NOVEL IMIDAZOTRIAZINONE OR IMIDAZOPYRAZINONE DERIVATIVES, AND USE THEREOF | ST PHARM CO., LTD. (KR) | 2017-06-15 | — | — | US | disclosed |
| US-20170145016-A1 | NOVEL TRIAZOLOPYRIMIDINONE OR TRIAZOLOPYRIDINONE DERIVATIVES, AND USE THEREOF | ST PHARM CO., LTD. (KR) | 2017-05-25 | — | — | US | disclosed |
| EP-3166946-A2 | NOVEL IMIDAZOTRIAZINONE OR IMIDAZOPYRAZINONE DERIVATIVES, AND USE THEREOF | ST Pharm Co. Ltd. (KR) | 2017-05-17 | — | — | EP | disclosed |
| EP-3166945-A2 | NOVEL TRIAZOLOPYRIMIDINONE OR TRIAZOLOPYRIDINONE DERIVATIVES, AND USE THEREOF | ST Pharm Co. Ltd. (KR) | 2017-05-17 | — | — | EP | disclosed |
| WO-2016006974-A2 | NOVEL TRIAZOLOPYRIMIDINONE OR TRIAZOLOPYRIDINONE DERIVATIVES, AND USE THEREOF | ST PHARM CO., LTD. (KR) | 2016-01-14 | — | — | WO | disclosed |
| WO-2016006975-A2 | NOVEL IMIDAZOTRIAZINONE OR IMIDAZOPYRAZINONE DERIVATIVES, AND USE THEREOF | ST PHARM CO., LTD. (KR) | 2016-01-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170145016-A1 | NOVEL TRIAZOLOPYRIMIDINONE OR TRIAZOLOPYRIDINONE DERIVATIVES, AND USE THEREOF | TNKS1BP1, TNKS, TPI1 | ALDH1A1 2244/4885SMN1; SMN2 1022/4885GAA 137/4885 |
| US-20180362538-A1 | Novel Dihydropyranopyrimidinone Derivatives, and Use Thereof | TNKS1BP1, TPI1, TNKS | ALDH1A1 855/4885SMN1; SMN2 893/4885GAA 23/4885 |
| US-20230242541-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | PLK1, BUB1B, BUB1 | ALDH1A1 4008/4885SMN1; SMN2 3089/4885GAA 2658/4885 |
| US-10179785-B2 | Imidazotriazinone or imidazopyrazinone derivatives, and use thereof | TNKS1BP1, TPI1, TPMT | ALDH1A1 1644/4885SMN1; SMN2 1247/4885GAA 74/4885 |
| US-20170166572-A1 | NOVEL IMIDAZOTRIAZINONE OR IMIDAZOPYRAZINONE DERIVATIVES, AND USE THEREOF | TNKS1BP1, TPI1, TBKBP1 | ALDH1A1 2275/4885SMN1; SMN2 1306/4885GAA 88/4885 |
| US-10336765-B2 | Dihydropyranopyrimidinone derivatives, and use thereof | TNKS1BP1, TPI1, TNKS | ALDH1A1 831/4885SMN1; SMN2 954/4885GAA 90/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.