Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14564412 | 0.76 | MAPT (0.48) | PTGDR2SMN1; SMN2ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL12984735 | 0.75 | KMO (0.52) | PTGDR2KMO | |
| SCHEMBL25357731 | 0.74 | MAPT (0.44) | PTGDR2ALDH1A1LMNATSHRPRMT5 | |
| SCHEMBL8415002 | 0.71 | MAPT (0.54) | PTGDR2SMN1; SMN2ALDH1A1LMNATSHR | |
| SCHEMBL29197706 | 0.69 | QDPR (0.45) | TBK1FABP4 | |
| SCHEMBL28555992 | 0.69 | PARP1 (0.43) | — | |
| SCHEMBL27552667 | 0.68 | ESR1 (0.41) | PTGDR2PRMT5WDR77 | |
| SCHEMBL11389386 | 0.67 | ACMSD (0.58) | PTGDR2SMN1; SMN2HTTL3MBTL1ACMSD | |
| SCHEMBL9323969 | 0.67 | AKR1B1 (0.51) | PTGDR2KMO | |
| SCHEMBL22406003 | 0.67 | KMT2A (0.41) | ALDH1A1LMNAHTTACMSDPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9725442-B2 | Heterocyclic derivative having PGD2 receptor antagonist activity | SHIONOGI & CO., LTD. (JP) | 2017-08-08 | — | — | US | disclosed |