Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TYR | P14679 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4521444 | 0.85 | L3MBTL1 (0.52) | L3MBTL1ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL27691054 | 0.84 | L3MBTL1 (0.55) | L3MBTL1ALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL5527102 | 0.82 | MAPT (0.69) | L3MBTL1ALDH1A1KMT2AMEN1GAA | |
| SCHEMBL18561603 | 0.82 | L3MBTL1 (0.44) | L3MBTL1ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL7837046 | 0.82 | ALDH1A1 (0.61) | L3MBTL1ALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL7593748 | 0.80 | L3MBTL1 (0.71) | L3MBTL1ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL7897640 | 0.80 | ALDH1A1 (0.50) | ALDH1A1HPGDKDM4ESMN1; SMN2GAA | |
| SCHEMBL31126451 | 0.79 | ALDH1A1 (0.51) | L3MBTL1ALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL11161289 | 0.79 | L3MBTL1 (0.57) | L3MBTL1ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL6920737 | 0.79 | ALDH1A1 (0.51) | L3MBTL1ALDH1A1KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102149697-A | 6-substituted benzoxazines as 5-HT-5A receptor antagonists | HOFFMANN LA ROCHE | 2011-08-10 | — | — | CN | claimed |
| CN-102149698-A | 5-substituted benzoxazines | HOFFMANN LA ROCHE | 2011-08-10 | — | — | CN | claimed |
| EP-2328881-A1 | 5-SUBSTITUTED BENZOXAZINES | F. Hoffmann-La Roche AG (CH) | 2011-06-08 | — | — | EP | claimed |
| EP-2328880-A2 | 6-SUBSTITUTED BENZOXAZINES AS 5-HT-5A RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2011-06-08 | — | — | EP | claimed |
| WO-2010026110-A2 | 6-SUBSTITUTED BENZOXAZINES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-11 | — | — | WO | claimed |
| WO-2010026112-A1 | 5-SUBSTITUTED BENZOXAZINES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-11 | — | — | WO | claimed |
| CN-108369222-B | Opioid receptor modulators and uses thereof | 明尼苏达大学董事会 | 2021-06-04 | — | — | CN | disclosed |
| EP-3344997-B1 | OPIOID RECEPTOR MODULATORS AND USE THEREOF | UNIV MINNESOTA (US) | 2020-11-18 | — | — | EP | disclosed |
| EP-3344997-B1 | OPIOID RECEPTOR MODULATORS AND USE THEREOF | UNIV MINNESOTA (US) | 2020-11-18 | — | — | EP | disclosed |
| CN-108369222-A | Opioid receptor modulators and uses thereof | 明尼苏达大学董事会 | 2018-08-03 | — | — | CN | disclosed |
| EP-3344997-A1 | OPIOID RECEPTOR MODULATORS AND USE THEREOF | Regents of the University of Minnesota (US) | 2018-07-11 | — | — | EP | disclosed |
| US-9827228-B2 | Opioid receptor modulators and use thereof | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2017-11-28 | — | — | US | disclosed |
| US-9827228-B2 | Opioid receptor modulators and use thereof | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2017-11-28 | — | — | US | disclosed |
| CN-102149697-A | 6-substituted benzoxazines as 5-HT-5A receptor antagonists | HOFFMANN LA ROCHE | 2011-08-10 | — | — | CN | disclosed |
| EP-2328881-A1 | 5-SUBSTITUTED BENZOXAZINES | F. Hoffmann-La Roche AG (CH) | 2011-06-08 | — | — | EP | disclosed |
| EP-2328880-A2 | 6-SUBSTITUTED BENZOXAZINES AS 5-HT-5A RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010026110-A2 | 6-SUBSTITUTED BENZOXAZINES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010026112-A1 | 5-SUBSTITUTED BENZOXAZINES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-11 | — | — | WO | disclosed |
| US-20100063042-A1 | 5-SUBSTITUTED BENZOXAZINES | HOFFMANN-LA ROCHE, INC. | 2010-03-11 | — | — | US | disclosed |
| US-20100063037-A1 | 6-SUBSTITUTED BENZOXAZINES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063042-A1 | 5-SUBSTITUTED BENZOXAZINES | HTR5A, NPY5R, GABRA5 | L3MBTL1 3742/4885ALDH1A1 1885/4885HPGD 1530/4885 |
| US-20100063037-A1 | 6-SUBSTITUTED BENZOXAZINES | HTR5A, NPY5R, GABRA5 | L3MBTL1 3586/4885ALDH1A1 1883/4885HPGD 1515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.