Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 2/20 | 0.37 |
| ▸ | RXRB | P28702 | 2/20 | 0.37 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30354629 | 0.85 | RXRA (0.51) | MAPTPYCR1MEN1KMT2ANPSR1 | |
| SCHEMBL5985 | 0.85 | RXRA (0.51) | MAPTPYCR1MEN1KMT2ANPSR1 | |
| SCHEMBL3474780 | 0.83 | SIRT1 (0.42) | MAPTPYCR1MEN1KMT2ANPSR1 | |
| SCHEMBL15658116 | 0.81 | MAPT (0.46) | MAPTMAPK1CYP3A4CUL4AGAA | |
| SCHEMBL9539850 | 0.80 | MEN1 (0.44) | MAPTPYCR1MEN1KMT2ACYP3A4 | |
| SCHEMBL13751380 | 0.80 | HPGD (0.45) | MAPTPYCR1MEN1KMT2AALDH1A1 | |
| SCHEMBL4050941 | 0.80 | NPC1 (0.45) | PYCR1MEN1KMT2ACYP3A4NPSR1 | |
| SCHEMBL2254145 | 0.80 | MTNR1A (0.48) | MAPTPYCR1MEN1KMT2ANPSR1 | |
| SCHEMBL8444 | 0.79 | DGAT1 (0.46) | MAPTMAPK1PYCR1MEN1KMT2A | |
| SCHEMBL16097462 | 0.79 | KDM4E (0.43) | MAPTMAPK1CYP3A4CUL4APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328902-A1 | PYRAZOLO [5,1-B]OXAZOLE DERIVATIVES AS CRF1 ANTAGONISTS | Novartis AG (CH) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010015628-A1 | PYRAZOLO [5,1-B] OXAZOLE DERIVATIVES AS CRF1 ANTAGONISTS | NOVARTIS AG (CH) | 2010-02-11 | — | — | WO | disclosed |