Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.56 |
| ▸ | FXR2 | P51116 | 1/20 | 0.54 |
| ▸ | FABP1 | P07148 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19230624 | 0.88 | NR1H4 (0.70) | NR1H4FXR2 | |
| SCHEMBL19230792 | 0.87 | NR1H4 (0.58) | NR1H4FXR2FABP1 | |
| SCHEMBL19230774 | 0.87 | NR1H4 (0.54) | NR1H4FXR2FABP1 | |
| SCHEMBL19230758 | 0.85 | NR1H4 (0.58) | NR1H4FXR2 | |
| SCHEMBL18724891 | 0.83 | NR1H4 (0.71) | NR1H4FXR2 | |
| SCHEMBL19230765 | 0.82 | NR1H4 (0.56) | NR1H4FXR2FABP1 | |
| SCHEMBL19230803 | 0.80 | NR1H4 (0.55) | NR1H4FABP1 | |
| SCHEMBL12168836 | 0.80 | NR1H4 (0.68) | NR1H4FXR2FABP1 | |
| SCHEMBL29904908 | 0.80 | NR1H4 (0.68) | NR1H4FXR2FABP1 | |
| SCHEMBL29904882 | 0.79 | NR1H4 (0.64) | NR1H4FXR2FABP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017133521-A1 | FXR RECEPTOR AGONIST | 山东轩竹医药科技有限公司 | 2017-08-10 | — | — | WO | disclosed |
| US-20150307452-A1 | NOVEL PYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307452-A1 | NOVEL PYRIDINE DERIVATIVES | NDUFS6, NDUFS3, NDUFV2 | NR1H4 470/4885FXR2 2637/4885FABP1 2644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.