Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 8/20 | 0.47 |
| ▸ | CFD | P00746 | 4/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19234311 | 0.90 | GID4 (0.44) | CFDDPP8DPP9DPP7GID4 | |
| SCHEMBL19234184 | 0.88 | P2RX7 (0.50) | P2RX7CFD | |
| SCHEMBL19234025 | 0.81 | MAPT (0.47) | CFDDPP8DPP9DPP7ALDH1A1 | |
| SCHEMBL19233889 | 0.81 | P2RX7 (0.48) | P2RX7CFDDPP8DPP9DPP7 | |
| SCHEMBL19234012 | 0.77 | MC4R (0.57) | DPP8DPP9DPP7CACNA1GALDH1A1 | |
| SCHEMBL12480319 | 0.75 | P2RX7 (0.51) | P2RX7CFD | |
| SCHEMBL29095042 | 0.75 | P2RX7 (0.51) | P2RX7CFD | |
| SCHEMBL30052463 | 0.75 | P2RX7 (0.51) | P2RX7CFD | |
| SCHEMBL30051988 | 0.75 | P2RX7 (0.51) | P2RX7CFD | |
| SCHEMBL18309345 | 0.75 | P2RX7 (0.51) | P2RX7CFD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2661433-B1 | INDOLE COMPOUNDS OR ANALOGUES THEREOF USEFUL FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD) | NOVARTIS AG (CH) | 2017-08-16 | — | — | EP | disclosed |