Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | CFD | P00746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MC4R | P32245 | 2/20 | 0.44 |
| ▸ | MC1R | Q01726 | 2/20 | 0.44 |
| ▸ | MC3R | P41968 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19234311 | 0.82 | GID4 (0.44) | CFDDPP8DPP9DPP7 | |
| SCHEMBL19234012 | 0.82 | MC4R (0.57) | F2ALDH1A1TSHRMC4RDPP8 | |
| SCHEMBL19234280 | 0.81 | CFD (0.46) | F2CFDMC4RDPP8DPP9 | |
| SCHEMBL19234388 | 0.81 | P2RX7 (0.47) | P2RX7CFDALDH1A1DPP8DPP9 | |
| SCHEMBL8302927 | 0.79 | MAPT (0.43) | P2RX7F2MAPTMEN1KMT2A | |
| SCHEMBL8302932 | 0.79 | MAPT (0.43) | P2RX7F2MAPTMEN1KMT2A | |
| SCHEMBL19234184 | 0.79 | P2RX7 (0.50) | P2RX7CFD | |
| SCHEMBL8304059 | 0.78 | HTR2C (0.55) | P2RX7MAPTMEN1KMT2AMC4R | |
| SCHEMBL8304057 | 0.78 | HTR2C (0.55) | P2RX7MAPTMEN1KMT2AMC4R | |
| SCHEMBL19234025 | 0.73 | MAPT (0.47) | CFDMAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2661433-B1 | INDOLE COMPOUNDS OR ANALOGUES THEREOF USEFUL FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD) | NOVARTIS AG (CH) | 2017-08-16 | — | — | EP | disclosed |