Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 1.00 |
| ▸ | GAA | P10253 | 6/20 | 1.00 |
| ▸ | HTT | P42858 | 4/20 | 1.00 |
| ▸ | POLB | P06746 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | JAK2 | O60674 | 1/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | MPI | P34949 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | MCL1 | Q07820 | 1/20 | 1.00 |
| ▸ | SHBG | P04278 | 1/20 | 0.82 |
| ▸ | GLA | P06280 | 2/20 | 0.61 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19236367 | 0.89 | KDM4E (0.79) | KDM4EGAAHTTPOLBMAPT | |
| SCHEMBL14317878 | 0.84 | SHBG (0.73) | KDM4EGAAHTTPOLBMAPT | |
| SCHEMBL14317876 | 0.82 | SHBG (0.70) | KDM4EGAAHTTPOLBMAPT | |
| SCHEMBL2791744 | 0.81 | GAA (0.67) | KDM4EGAAHTTPOLBMAPT | |
| SCHEMBL8745765 | 0.79 | KDM4E (0.65) | KDM4EGAAHTTPOLBMAPT | |
| SCHEMBL14924903 | 0.79 | KDM4E (0.65) | KDM4EGAAHTTPOLBMAPT | |
| SCHEMBL31414410 | 0.77 | KDM4E (0.61) | KDM4EGAAHTTPOLBMAPT | |
| SCHEMBL15285080 | 0.77 | KDM4E (0.61) | KDM4EGAAHTTPOLBMAPT | |
| SCHEMBL29528063 | 0.77 | SHBG (0.67) | KDM4EGAAHTTPOLBMAPT | |
| SCHEMBL7797770 | 0.77 | KDM4E (0.74) | KDM4EGAAHTTPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056914-A1 | BACTERIAL HELICASE INHIBITOR COMPOUNDS AND USES THEREOF | MICROBIOTIX, INC. (US) | 2010-05-20 | — | — | WO | claimed |
| WO-2010056914-A1 | BACTERIAL HELICASE INHIBITOR COMPOUNDS AND USES THEREOF | MICROBIOTIX, INC. (US) | 2010-05-20 | — | — | WO | disclosed |
| WO-2010056914-A1 | BACTERIAL HELICASE INHIBITOR COMPOUNDS AND USES THEREOF | MICROBIOTIX, INC. (US) | 2010-05-20 | — | — | WO | disclosed |