Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1924167 | 0.82 | ALOX15 (0.44) | SMN1; SMN2 | |
| SCHEMBL4553629 | 0.81 | ALDH1A1 (0.72) | ALDH1A1 | |
| SCHEMBL8504135 | 0.78 | NR4A2 (0.68) | NR4A2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8352535 | 0.78 | NR4A2 (0.72) | NR4A2ALDH1A1 | |
| SCHEMBL11578762 | 0.76 | NR4A2 (0.65) | NR4A2ALDH1A1SMN1; SMN2 | |
| SCHEMBL7327889 | 0.76 | NR4A2 (0.65) | NR4A2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11578765 | 0.75 | NR4A2 (0.63) | NR4A2ALDH1A1 | |
| SCHEMBL10831591 | 0.75 | ALDH1A1 (0.52) | ALDH1A1 | |
| SCHEMBL5137730 | 0.74 | NR4A2 (1.00) | NR4A2ALDH1A1 | |
| SCHEMBL10986271 | 0.74 | ALDH1A1 (0.45) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874777-B1 | 1H-PYRIMIDO[4,5-B]INDOLE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE | SANOFI AVENTIS (FR) | 2011-06-08 | — | — | EP | disclosed |
| US-20090215741-A1 | 1H-Pyrimido[4,5-b]indole Derivatives, Their Preparation and Therapeutic Use | SANOFI-AVENTIS (FR) | 2009-08-27 | — | — | US | disclosed |
| US-7547706-B2 | 1H-pyrimido[4,5-b]indole derivatives, their preparation and therapeutic use | SANOFI-AVENTIS (FR) | 2009-06-16 | — | — | US | disclosed |
| US-20080125410-A1 | 7-chloro-N,N-9-trimethyl-2-(6-methylpyridin-3-yl)-9H-pyrimido[4,5-b]indole-4-carboxamide; ethyl 7-chloro-9-methyl-2-phenyl-9H-pyrimido[4,5-b]indole-4-carboxylate; 4-[(4-azetidin-1-yl)piperidin-1-ylcarbonyl]-7-chloro-9-methyl-2-phenyl-9H-pyrimido-[4,5-b]indole; Alzheimer's or Parkinson's disease | SANOFI-AVENTIS (FR) | 2008-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215741-A1 | 1H-Pyrimido[4,5-b]indole Derivatives, Their Preparation and Therapeutic Use | IDO1, IDO2, TPH1 | NR4A2 2732/4885ALDH1A1 107/4885SMN1; SMN2 901/4885 |
| US-20080125410-A1 | 7-chloro-N,N-9-trimethyl-2-(6-methylpyridin-3-yl)-9H-pyrimido[4,5-b]indole-4-carboxamide; ethyl 7-chloro-9-methyl-2-phenyl-9H-pyrimido[4,5-b]indole-4-carboxylate; 4-[(4-azetidin-1-yl)piperidin-1-ylcarbonyl]-7-chloro-9-methyl-2-phenyl-9H-pyrimido-[4,5-b]indole; Alzheimer's or Parkinson's disease | PARK7, SNCA, PSEN2 | NR4A2 729/4885ALDH1A1 777/4885SMN1; SMN2 436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.