Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 11/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.51 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.46 |
| ▸ | KIT | P10721 | 3/20 | 0.46 |
| ▸ | FLT3 | P36888 | 3/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.46 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | GOT1 | P17174 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1925334 | 0.90 | EPHX2 (0.48) | MEN1MAPTKMT2AKDRGOT1 | |
| SCHEMBL1925039 | 0.88 | RIPK1 (0.44) | MEN1MAPTHTTRAB9AKMT2A | |
| SCHEMBL1925038 | 0.88 | ROCK2 (0.46) | MEN1MAPTRAB9AKMT2AKDR | |
| SCHEMBL1925178 | 0.86 | KDR (0.49) | KDRPDGFRBAURKBKITFLT3 | |
| SCHEMBL1925429 | 0.86 | RIPK1 (0.46) | MEN1MAPTKMT2AKDRPDGFRB | |
| SCHEMBL1924620 | 0.86 | CSF1R (0.53) | MEN1MAPTKMT2AKDRPDGFRB | |
| SCHEMBL1924020 | 0.85 | CDK8 (0.43) | KDRAURKBKITFLT3NTRK1 | |
| SCHEMBL1924893 | 0.84 | KDR (0.51) | KDRCDK8RIPK1 | |
| SCHEMBL1924795 | 0.84 | CDK8 (0.44) | KDRPDGFRBRETCDK8EPHX2 | |
| SCHEMBL1923760 | 0.84 | MEN1 (0.56) | MEN1MAPTHTTRAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856043-B1 | 1-H-PYRROLE-2-CARBOXAMIDES AND IMIDAZOLE-5-CARBOXAMIDES AND USE THEREOF AS FAK, KDR AND TIE2 KINASE MODULATORS FOR THE TREATMENT OF CANCER | AVENTIS PHARMA SA (FR) | 2011-06-08 | — | — | EP | claimed |