Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 6/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.47 |
| ▸ | LTK | P29376 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 5/20 | 0.46 |
| ▸ | CSF1R | P07333 | 4/20 | 0.46 |
| ▸ | FLT1 | P17948 | 4/20 | 0.46 |
| ▸ | LCK | P06239 | 3/20 | 0.46 |
| ▸ | FLT4 | P35916 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1925429 | 0.90 | RIPK1 (0.46) | KDRPDGFRBCA12CA1CA2 | |
| SCHEMBL1925334 | 0.90 | EPHX2 (0.48) | KDRCA12CA1CA2CA9 | |
| SCHEMBL1924020 | 0.86 | CDK8 (0.43) | KDRFLT3AURKBNTRK1RET | |
| SCHEMBL1923967 | 0.86 | MEN1 (0.51) | KDRPDGFRBFLT3AURKBNTRK1 | |
| SCHEMBL1923687 | 0.86 | CA12 (0.57) | KDRPDGFRBCA12CA1CA2 | |
| SCHEMBL1925039 | 0.86 | RIPK1 (0.44) | KDRPDGFRBCA12CA1CA2 | |
| SCHEMBL1925337 | 0.85 | PKM (0.47) | KDRPDGFRBCA12CA1CA2 | |
| SCHEMBL1924035 | 0.84 | CA12 (0.53) | KDRPDGFRBCA12CA1CA2 | |
| SCHEMBL1923690 | 0.84 | CA12 (0.55) | KDRPDGFRBCA12CA1CA2 | |
| SCHEMBL1924576 | 0.84 | CA12 (0.55) | KDRPDGFRBCA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856043-B1 | 1-H-PYRROLE-2-CARBOXAMIDES AND IMIDAZOLE-5-CARBOXAMIDES AND USE THEREOF AS FAK, KDR AND TIE2 KINASE MODULATORS FOR THE TREATMENT OF CANCER | AVENTIS PHARMA SA (FR) | 2011-06-08 | — | — | EP | claimed |