Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.46 |
| ▸ | TEK | Q02763 | 2/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1925178 | 0.90 | KDR (0.49) | RIPK1TEKFLT1KDRNTRK1 | |
| SCHEMBL1925334 | 0.89 | EPHX2 (0.48) | MAPTMEN1KMT2AKDRCA12 | |
| SCHEMBL1924893 | 0.87 | KDR (0.51) | RIPK1KDRCA1CA2CA9 | |
| SCHEMBL1923967 | 0.86 | MEN1 (0.51) | RIPK1FLT1MAPTMEN1KMT2A | |
| SCHEMBL1925039 | 0.85 | RIPK1 (0.44) | RIPK1MAPTMEN1KMT2AKDR | |
| SCHEMBL1925498 | 0.85 | RIPK1 (0.49) | RIPK1TEKFLT1CHRNA7MAPT | |
| SCHEMBL1924459 | 0.82 | KDM4E (0.46) | FLT1MAPTGAAMEN1KMT2A | |
| SCHEMBL1924020 | 0.80 | CDK8 (0.43) | RIPK1FLT1KDRNTRK1 | |
| SCHEMBL1924464 | 0.80 | ALDH1A1 (0.38) | TEKMAPTMEN1KMT2AKDR | |
| SCHEMBL1925914 | 0.80 | CA12 (0.49) | RIPK1FLT1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856043-B1 | 1-H-PYRROLE-2-CARBOXAMIDES AND IMIDAZOLE-5-CARBOXAMIDES AND USE THEREOF AS FAK, KDR AND TIE2 KINASE MODULATORS FOR THE TREATMENT OF CANCER | AVENTIS PHARMA SA (FR) | 2011-06-08 | — | — | EP | claimed |