Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19964551 | 0.84 | SMN1; SMN2 (0.55) | LMNASMN1; SMN2CACNA1HCACNA1BCACNA1C | |
| SCHEMBL19249105 | 0.84 | CTSV (0.46) | LMNAHPGDSMN1; SMN2CACNA1HCACNA1B | |
| SCHEMBL19248869 | 0.83 | GABRA1 (0.48) | SMN1; SMN2CACNA1HCACNA1BCACNA1CMTNR1A | |
| SCHEMBL19249202 | 0.83 | GABRA1 (0.48) | HPGDSMN1; SMN2MTNR1AMTNR1BKDM4A | |
| SCHEMBL19211135 | 0.81 | LMNA (0.54) | LMNAHPGDPRNPCYP1A2CYP2C9 | |
| SCHEMBL9177217 | 0.81 | L3MBTL1 (0.42) | SMN1; SMN2CACNA1HCACNA1BCACNA1CKDM4A | |
| SCHEMBL19248971 | 0.80 | GABRA1 (0.52) | SMN1; SMN2CACNA1HCACNA1BCACNA1CCYP1A2 | |
| SCHEMBL20729434 | 0.78 | PRMT5 (0.53) | — | |
| SCHEMBL19249119 | 0.78 | DRD4 (0.38) | LMNAHPGDSMN1; SMN2CACNA1HCACNA1B | |
| SCHEMBL7319151 | 0.76 | IDO1 (0.58) | CAMK2DMTNR1AMTNR1BHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414229-B1 | QUINOLINONE LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA INC (US) | 2021-06-16 | — | — | EP | disclosed |
| WO-2017139274-A1 | QUINOLINONE LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2017-08-17 | — | — | WO | disclosed |