Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.53 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.53 |
| ▸ | GSK3B | P49841 | 10/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 10/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19211308 | 0.86 | GSK3B (0.49) | PRMT5WDR77GSK3BDYRK1ALOXL2 | |
| SCHEMBL19249202 | 0.84 | GABRA1 (0.48) | — | |
| SCHEMBL20438078 | 0.80 | PRMT5 (0.48) | PRMT5WDR77GSK3BDYRK1ALOXL2 | |
| SCHEMBL19248970 | 0.78 | LMNA (0.46) | — | |
| SCHEMBL19249203 | 0.78 | P2RY14 (0.43) | — | |
| SCHEMBL19249105 | 0.77 | CTSV (0.46) | — | |
| SCHEMBL22918922 | 0.77 | GSK3B (0.54) | PRMT5WDR77GSK3BDYRK1ARET | |
| SCHEMBL19211254 | 0.77 | LOXL2 (0.71) | PRMT5WDR77GSK3BDYRK1ALOXL2 | |
| Hydrochloric Acid SCHEMBL19211241 | 0.76 | LOXL2 (0.70) | PRMT5WDR77GSK3BDYRK1ALOXL2 | |
| SCHEMBL19248869 | 0.76 | GABRA1 (0.48) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11058676-B2 | Quinolinone lysyl oxidase-like 2 inhibitors and uses thereof | PHARMAKEA, INC. (US) | 2021-07-13 | — | — | US | disclosed |
| US-10588900-B2 | Quinolinone lysyl oxidase-like 2 inhibitors and uses thereof | PHARMAKEA, INC. (US) | 2020-03-17 | — | — | US | disclosed |
| US-20190046520-A1 | QUINOLINONE LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. | 2019-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11058676-B2 | Quinolinone lysyl oxidase-like 2 inhibitors and uses thereof | LOXL2, LOXL1, LOX | PRMT5 2180/4885WDR77 2269/4885GSK3B 1778/4885 |
| US-20190046520-A1 | QUINOLINONE LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | LOXL2, LOXL1, LOX | PRMT5 2180/4885WDR77 2269/4885GSK3B 1778/4885 |
| US-10588900-B2 | Quinolinone lysyl oxidase-like 2 inhibitors and uses thereof | LOXL2, LOXL1, LOX | PRMT5 2180/4885WDR77 2269/4885GSK3B 1778/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.