Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 12/20 | 0.45 |
| ▸ | TDO2 | P48775 | 11/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19249080 | 0.85 | IDO1 (0.51) | IDO1TDO2SLC6A4HTR6 | |
| SCHEMBL19249340 | 0.77 | PTGER1 (0.37) | IDO1TDO2MAPTMAPK1NPSR1 | |
| SCHEMBL19249341 | 0.76 | IDO1 (0.42) | IDO1TDO2MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL28449826 | 0.75 | TDO2 (0.67) | IDO1TDO2PKMMAPTMEN1 | |
| SCHEMBL17440906 | 0.74 | IDO1 (0.51) | IDO1TDO2 | |
| SCHEMBL19249082 | 0.73 | RXRA (0.48) | IDO1TDO2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19248989 | 0.73 | MRGPRX4 (0.53) | IDO1TDO2MEN1KMT2ANPC1 | |
| SCHEMBL17440928 | 0.72 | MAOB (0.45) | IDO1TDO2MAPTMEN1KMT2A | |
| SCHEMBL19248986 | 0.71 | CCR5 (0.48) | IDO1TDO2MAPTMEN1KMT2A | |
| SCHEMBL19249081 | 0.71 | MAPT (0.46) | IDO1TDO2PKMMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017133258-A1 | 1H-INDAZOLE DERIVATIVE AND USE THEREOF AS IDO INHIBITOR | 西华大学 | 2017-08-10 | — | — | WO | disclosed |