Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 3/20 | 0.46 |
| ▸ | BCHE | P06276 | 8/20 | 0.42 |
| ▸ | ACHE | P22303 | 8/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19249245 | 0.80 | PLA2G2A (0.46) | PLA2G2AKCNH2MTNR1AMTNR1BKDM4E | |
| SCHEMBL31587770 | 0.77 | KDM4E (0.56) | PLA2G2ABCHEACHEKDM4EMEN1 | |
| SCHEMBL13214422 | 0.75 | KDM4E (0.47) | KCNH2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL3022280 | 0.73 | KCNH2 (0.46) | PLA2G2AKCNH2MTNR1AMTNR1BKDM4E | |
| SCHEMBL3025700 | 0.72 | KDM4E (0.47) | PLA2G2AKCNH2HTR1AADRA1DADRA1A | |
| SCHEMBL13234527 | 0.71 | KDM4E (0.43) | KCNH2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL13234908 | 0.71 | KDM4E (0.43) | KCNH2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL10949246 | 0.70 | MEN1 (0.47) | PLA2G2AKDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3025917 | 0.70 | KCNH2 (0.48) | PLA2G2AKCNH2MTNR1AMTNR1BKDM4E | |
| SCHEMBL19249244 | 0.69 | CA2 (0.40) | PLA2G2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017139274-A1 | QUINOLINONE LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2017-08-17 | — | — | WO | disclosed |