Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 3/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | BRD4 | O60885 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19249244 | 0.90 | CA2 (0.40) | PLA2G2ADYRK1AKDM4EMAPT | |
| SCHEMBL19248870 | 0.89 | EGLN2 (0.40) | HSD17B10 | |
| SCHEMBL19248872 | 0.89 | NQO2 (0.43) | PLA2G2ADYRK1ANPC1RAB9AL3MBTL1 | |
| SCHEMBL19249247 | 0.86 | MMP13 (0.47) | PLA2G2ADYRK1AMTNR1AMTNR1BSLC2A1 | |
| SCHEMBL19249249 | 0.80 | PLA2G2A (0.46) | PLA2G2AMTNR1AMTNR1BKCNH2KDM4E | |
| SCHEMBL20729415 | 0.79 | BCHE (0.43) | PLA2G2ADYRK1ASLC2A1BRD4KDM4E | |
| SCHEMBL13191484 | 0.79 | CNR1 (0.49) | MTNR1AMTNR1BTSHRGFERHSD17B10 | |
| SCHEMBL19248874 | 0.78 | EGLN2 (0.42) | PLA2G2AKDM4ENPC1RAB9AMAPT | |
| SCHEMBL23491567 | 0.77 | HDAC1 (0.41) | PLA2G2ADYRK1AMTNR1AMTNR1BSLC2A1 | |
| SCHEMBL19248873 | 0.75 | NQO2 (0.45) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017139274-A1 | QUINOLINONE LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2017-08-17 | — | — | WO | disclosed |