SCHEMBL1924992

SCHEMBL1924992

CCNc1cccc(N)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.52
MEN1 O00255 2/20 0.52
GAA P10253 2/20 0.52
KMT2A Q03164 2/20 0.52
TDP1 Q9NUW8 2/20 0.52
KDM4E B2RXH2 1/20 0.52
LMNA P02545 1/20 0.52
GFER P55789 1/20 0.52
ALDH1A1 P00352 6/20 0.50
DDX3X O00571 2/20 0.48
RAPGEF4 Q8WZA2 1/20 0.47
CYP3A4 P08684 4/20 0.46
CASP1 P29466 1/20 0.46
RECQL P46063 1/20 0.46
TP53 P04637 1/20 0.44
CYP1A2 P05177 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
HTT P42858 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL28170166 0.98 MAPT (0.50) MAPTMEN1GAAKMT2ATDP1
SCHEMBL3363357 0.84 MAPT (0.50) MAPTMEN1KMT2AKDM4ELMNA
SCHEMBL29922677 0.83 MAPT (0.48) MAPTMEN1GAAKMT2ATDP1
SCHEMBL4745533 0.83 MAPT (0.48) MAPTMEN1GAAKMT2ATDP1
SCHEMBL8168701 0.80 F2R (0.47) MAPTMEN1GAAKMT2ATDP1
Aniline SCHEMBL9780950 0.80 LMNA (0.52) MAPTMEN1GAAKMT2ATDP1
SCHEMBL21799457 0.79 MAPT (0.44) MAPTMEN1GAAKMT2ATDP1
SCHEMBL21799640 0.79 MAPT (0.44) MAPTMEN1GAAKMT2ATDP1
SCHEMBL29922565 0.79 MAPT (0.44) MAPTMEN1GAAKMT2ATDP1
SCHEMBL4611763 0.79 ABL1 (0.47) MAPTMEN1GAAKMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 127 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111971119-B Heterogeneous catalyst for carbamate synthesis 科思创知识产权两合公司 2023-12-08 CN claimed
US-11406964-B2 Heterogeneous catalysts for the synthesis of carbamates COVESTRO INTELLECTUAL PROPERTY GMBH & CO. KG (DE) 2022-08-09 US claimed
CN-110650944-B Silica-based zinc catalysts, their preparation and use in the alkoxycarbonylation of amines 科思创德国股份有限公司 2022-07-19 CN claimed
EP-3625210-B1 SILICA-BASED ZINC CATALYSTS. THEIR PREPARATION AND USE IN THE ALKOXYCARBONYLATION OF AMINES COVESTRO INTELLECTUAL PROPERTY GMBH & CO KG (DE) 2021-06-23 EP claimed
US-20210053031-A1 HETEROGENEOUS CATALYSTS FOR THE SYNTHESIS OF CARBAMATES COVESTRO INTELLECTUAL PROPERTY GMBH & CO. KG (DE) 2021-02-25 US claimed
CN-105229015-B Zinc cluster compounds and their use as catalysts in the reaction of amines with dialkyl carbonates 科思创德国股份公司 2020-11-03 CN claimed
US-10807084-B2 Silica-based zinc catalysts, their preparation and use in the alkoxycarbonylation of amines COVESTRO DEUTSCHLAND AG (DE) 2020-10-20 US claimed
US-20200147594-A1 SILICA-BASED ZINC CATALYSTS, THEIR PREPARATION AND USE IN THE ALKOXYCARBONYLATION OF AMINES COVESTRO DEUTSCHLAND AG (DE) 2020-05-14 US claimed
EP-3625210-A1 SILICA-BASED ZINC CATALYSTS. THEIR PREPARATION AND USE IN THE ALKOXYCARBONYLATION OF AMINES Covestro Deutschland AG (DE) 2020-03-25 EP claimed
CN-110650944-A Silica-based zinc catalysts, their preparation and use in the alkoxycarbonylation of amines 科思创德国股份有限公司 2020-01-03 CN claimed
US-20160194277-A1 ZINC CLUSTER COMPOUNDS AND THEIR USE AS CATALYSTS IN THE REACTION OF AMINES WITH DIALKYL CARBONATES COVESTRO DEUTSCHLAND AG (DE) 2016-07-07 US claimed
EP-2999705-A1 ZINC CLUSTER COMPOUNDS AND THEIR USE AS CATALYSTS IN THE REACTION OF AMINES WITH DIALKYL CARBONATES Covestro Deutschland AG (DE) 2016-03-30 EP claimed
US-9278906-B2 Process for hydrogenating aromatic di- and polyamines to cycloaliphatic di- and polyamines BAYER MATERIALSCIENCE AG (DE) 2016-03-08 US claimed
CN-105229015-A Zinc cluster compounds and their use as catalysts in the reaction of amines with dialkyl carbonates BAYER MATERIALSCIENCE AG 2016-01-06 CN claimed
EP-2905273-A1 Process for hydrogenating aromatic di- and polyamines Bayer MaterialScience AG (DE) 2015-08-12 EP claimed
EP-2905272-A1 Process for hydrogenating aromatic di- and polyamines to cycloaliphatic di- and polyamines Bayer MaterialScience AG (DE) 2015-08-12 EP claimed
US-20150218082-A1 PROCESS FOR HYDROGENATING AROMATIC DI- AND POLYAMINES COVESTRO DEUTSCHLAND AG (DE) 2015-08-06 US claimed
US-20150218083-A1 PROCESS FOR HYDROGENATING AROMATIC DI- AND POLYAMINES TO CYCLOALIPHATIC DI- AND POLYAMINES COVESTRO DEUTSCHLAND AG (DE) 2015-08-06 US claimed
CN-104817460-A Process for hydrogenating aromatic di- and polyamines BAYER MATERIALSCIENCE AG 2015-08-05 CN claimed
CN-104817459-A Process for hydrogenating aromatic di- and polyamines to cycloaliphatic di- and polyamines BAYER MATERIALSCIENCE AG 2015-08-05 CN claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200147594-A1 SILICA-BASED ZINC CATALYSTS, THEIR PREPARATION AND USE IN THE ALKOXYCARBONYLATION OF AMINES CDYL, ZYX, CXXC4 MAPT 3375/4885MEN1 2092/4885GAA 1532/4885
US-20150218083-A1 PROCESS FOR HYDROGENATING AROMATIC DI- AND POLYAMINES TO CYCLOALIPHATIC DI- AND POLYAMINES DDT, HRH3, HRH4 MAPT 2582/4885MEN1 1146/4885GAA 1380/4885
US-20210053031-A1 HETEROGENEOUS CATALYSTS FOR THE SYNTHESIS OF CARBAMATES SCO2, CDYL, PYM1 MAPT 1340/4885MEN1 2958/4885GAA 617/4885
US-11406964-B2 Heterogeneous catalysts for the synthesis of carbamates SCO2, CDYL, PYM1 MAPT 1340/4885MEN1 2958/4885GAA 617/4885
US-20150218082-A1 PROCESS FOR HYDROGENATING AROMATIC DI- AND POLYAMINES HNMT, DDT, HRH3 MAPT 3358/4885MEN1 1229/4885GAA 1741/4885
US-20160194277-A1 ZINC CLUSTER COMPOUNDS AND THEIR USE AS CATALYSTS IN THE REACTION OF AMINES WITH DIALKYL CARBONATES AOC1, AOC2, ODC1 MAPT 4142/4885MEN1 1337/4885GAA 880/4885
US-10807084-B2 Silica-based zinc catalysts, their preparation and use in the alkoxycarbonylation of amines CDYL, ZYX, CXXC4 MAPT 3375/4885MEN1 2092/4885GAA 1532/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.