Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.56 |
| ▸ | LOX | P28300 | 2/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CCR9 | P51686 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19251359 | 0.87 | LOXL2 (0.59) | LOXL2LOXFFAR1SLC13A5ENPP2 | |
| SCHEMBL19251200 | 0.83 | LOXL2 (0.54) | LOXL2LOXFFAR1SLC13A5ENPP2 | |
| SCHEMBL2092744 | 0.79 | LOXL2 (0.67) | LOXL2LOXFFAR1SLC13A5ENPP2 | |
| SCHEMBL19251203 | 0.79 | NOS3 (0.53) | LOXL2LOXAAK1NPC1NUDT1 | |
| SCHEMBL13028811 | 0.78 | LOXL2 (0.65) | LOXL2LOXFFAR1SLC13A5CHRM1 | |
| SCHEMBL4379060 | 0.76 | LOXL2 (0.68) | LOXL2LOX | |
| SCHEMBL2092739 | 0.76 | LOXL2 (0.62) | LOXL2LOXFFAR1SLC13A5ENPP2 | |
| SCHEMBL21227110 | 0.75 | LOXL2 (0.61) | LOXL2LOXFFAR1SLC13A5CHRM1 | |
| SCHEMBL4018107 | 0.73 | LOXL2 (0.59) | LOXL2LOXFFAR1SLC13A5ENPP2 | |
| SCHEMBL805488 | 0.73 | LOXL2 (0.69) | LOXL2LOXFFAR1SLC13A5GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9878987-B2 | HSP70 modulators and methods for making and using the same | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2018-01-30 | — | — | US | disclosed |
| US-20170233352-A1 | HSP70 MODULATORS AND METHODS FOR MAKING AND USING THE SAME | MEMORIAL SLOAN KETTERING CANCER CENTER | 2017-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170233352-A1 | HSP70 MODULATORS AND METHODS FOR MAKING AND USING THE SAME | HSPA2, HSP90AA1, HSP90AB1 | LOXL2 4120/4885LOX 3053/4885FFAR1 4310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.