Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | GPR4 | P46093 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1490884 | 0.89 | TP53 (0.36) | TP53HTR2AHTR2BHTR2CKDM4E | |
| SCHEMBL3355085 | 0.88 | TLR7 (0.45) | KDM4EPDE4DTLR7 | |
| SCHEMBL191697 | 0.84 | LMNA (0.39) | TSHRTP53HTR2AHTR2BHTR2C | |
| SCHEMBL8565615 | 0.82 | TSHR (0.47) | TSHRMAPK1HTR2AHTR2BKDM4E | |
| SCHEMBL193507 | 0.80 | TLR7 (0.49) | HTR2AHTR2BPOLBLMNAHRH2 | |
| SCHEMBL4299553 | 0.80 | PDE10A (0.38) | TSHRMAPK1HTR2AHTR2BHTR2C | |
| SCHEMBL4056414 | 0.79 | ALDH1A1 (0.41) | TSHRTP53KDM4EPOLBLMNA | |
| SCHEMBL4302608 | 0.79 | KDM4E (0.40) | HTR2AHTR2BHTR2CKDM4EPDE10A | |
| SCHEMBL192091 | 0.77 | TSHR (0.38) | TSHRMAPK1TP53HTR2AHTR2B | |
| SCHEMBL841480 | 0.76 | ALDH1A1 (0.36) | MAPK1TP53HTR2AHTR2BHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833827-B9 | PROCESS FOR PREPARING 2-METHYL-1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C][1,5]NAPHTHYRIDIN-4-AMINE | MEDA AB (SE) | 2012-01-04 | — | — | EP | claimed |
| EP-1833827-B1 | PROCESS FOR PREPARING 2-METHYL-1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C][1,5]NAPHTHYRIDIN-4-AMINE | MEDA AB (SE) | 2011-05-25 | — | — | EP | claimed |