Sugi Predict

Sugi Predict / Compounds / Methylphenylsulfone

Methylphenylsulfone

Methylphenylsulfone

SCHEMBL1925243

CS(=O)(=O)c1ccccc1.O=S(=O)(Cl)Cl

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 1/20 0.59
▸ HSD17B10 Q99714 1/20 0.59
▸ TDP1 Q9NUW8 1/20 0.59
▸ PTGS2 P35354 9/20 0.56
▸ HTR6 P50406 1/20 0.50
▸ ENPP2 Q13822 2/20 0.48
▸ PSIP1 O75475 1/20 0.48
▸ CA12 O43570 1/20 0.46
▸ CA1 P00915 1/20 0.46
▸ CA2 P00918 1/20 0.46
▸ CA3 P07451 1/20 0.46
▸ CA4 P22748 1/20 0.46
▸ CA6 P23280 1/20 0.46
▸ CA5A P35218 1/20 0.46
▸ CA7 P43166 1/20 0.46
▸ PLA2G7 Q13093 1/20 0.46
▸ CA9 Q16790 1/20 0.46
▸ CA13 Q8N1Q1 1/20 0.46
▸ CA14 Q9ULX7 1/20 0.46
▸ CA5B Q9Y2D0 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methylphenylsulfone SCHEMBL1332357 0.92 PTGS2 (0.62) ALDH1A1HSD17B10TDP1PTGS2HTR6
Methylphenylsulfone SCHEMBL78253 0.92 PTGS2 (0.62) ALDH1A1HSD17B10TDP1PTGS2HTR6
Methylphenylsulfone SCHEMBL5499087 0.89 PTGS2 (0.60) ALDH1A1HSD17B10TDP1PTGS2HTR6
Methylphenylsulfone SCHEMBL28288198 0.86 PTGS2 (0.58) ALDH1A1HSD17B10TDP1PTGS2HTR6
Methylphenylsulfone SCHEMBL28158010 0.86 PTGS2 (0.58) ALDH1A1HSD17B10TDP1PTGS2HTR6
Methylphenylsulfone SCHEMBL28046614 0.86 PTGS2 (0.58) ALDH1A1HSD17B10TDP1PTGS2HTR6
Methylphenylsulfone SCHEMBL28097901 0.86 PTGS2 (0.58) ALDH1A1HSD17B10TDP1PTGS2HTR6
Methylphenylsulfone SCHEMBL11042562 0.85 PTGS2 (0.52) ALDH1A1HSD17B10TDP1PTGS2ENPP2
Methylphenylsulfone SCHEMBL11698567 0.84 PTGS2 (0.56) ALDH1A1HSD17B10TDP1PTGS2HTR6
Methylphenylsulfone SCHEMBL27930437 0.84 PTGS2 (0.56) ALDH1A1HSD17B10TDP1PTGS2HTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104678028-A Pretreatment and detection method for biogen amine neurotransmitter and detection kit INST PHARM & TOXICOLOGY AMMS 2015-06-03 — — CN claimed
JP-11335348-A — — None — — JP disclosed
CN-115286542-A Preparation method of sulfinate compound 浙江工业大学 2022-11-04 — — CN disclosed
CN-105837577-B 1- (pyrimidine-4-yl) 3- aminopiperidine derivatives and its preparation method and application 四川大学 2019-01-25 — — CN disclosed
EP-2509941-B1 N-ACYLATED HYDROXYLAMINE DERIVATIVES AND O-ACYLATED HYDROXYLAMINE DERIVATIVES UNIV JOHNS HOPKINS (US) 2019-01-23 — — EP disclosed
CN-105143206-B Pyrimidine -2,4- diamine derivative for treating cancer 托马斯·黑勒戴药物研究基金会 2019-01-15 — — CN disclosed
CN-105130855-B Succinylated hydroxy amine derivatives and application thereof 约翰斯霍普金斯大学 2018-05-25 — — CN disclosed
US-20180050985-A1 N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES THE JOHNS HOPKINS UNIVERSITY 2018-02-22 — — US disclosed
CN-104678028-B The pre-treatment of biological original amine neurotransmitters and detection method and detection kit 中国人民解放军军事医学科学院毒物药物研究所 2017-08-15 — — CN disclosed
CN-106794181-A MTH1 inhibitors for the treatment of inflammatory and autoimmune conditions 托马斯·黑勒戴药物研究基金会 2017-05-31 — — CN disclosed
CN-1368961-A Compounds that modulate PPAR γ activity TULARIK INC (US) 2002-09-11 — — CN disclosed
CN-1079097-C Heterobicyclic sulfonamide derivatives and sulfonate derivatives EISAI CO LTD (JP) 2002-02-13 — — CN disclosed
CN-1296008-A Dioxacyclopentedien-6-(5aH)-one compound, its preparation process and medicinal composition ADIR (FR) 2001-05-23 — — CN disclosed
CN-1283189-A Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors DIMENSIONAL PHARM INC (US) 2001-02-07 — — CN disclosed
CN-1281451-A Benzamidine derivatives MERCK PATENT GMBH (DE) 2001-01-24 — — CN disclosed
CN-1272107-A Benzamidine derivatives as factor Xa inhibitors MERCK PATENT GMBH (DE) 2000-11-01 — — CN disclosed
CN-1260345-A Hydrazide compound, its preparing method and medicine compositions thereof ADIR ET COMPANGIE (FR) 2000-07-19 — — CN disclosed
CN-1237961-A Aminoguanidines and alkoxyguanidines as protease inhibitors DIMENSIONAL PHARM INC (US) 1999-12-08 — — CN disclosed
JP-H11335348-A PRODUCTION OF CHLOROSULFONYLBENZENESULFONIC ACID SUMITOMO SEIKA CHEM CO LTD 1999-12-07 — — JP disclosed
CN-1114506-A Heterobicyclic sulfonamide derivatives and sulfonate derivatives EISAI CO LTD (JP) 1996-01-03 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180050985-A1 N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES TNNI3, TNNT2, NOS2 ALDH1A1 648/4885HSD17B10 292/4885TDP1 3283/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.