SCHEMBL19257724

SCHEMBL19257724

CC(CC(C)c1ccc(N)cc1)C(=O)O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIA4 P48058 1/20 0.41
ENPEP Q07075 2/20 0.40
POLB P06746 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
HDAC3 O15379 1/20 0.39
HDAC4 P56524 1/20 0.39
HDAC1 Q13547 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC2 Q92769 1/20 0.39
HDAC10 Q969S8 1/20 0.39
HDAC11 Q96DB2 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
HDAC9 Q9UKV0 1/20 0.39
HDAC5 Q9UQL6 1/20 0.39
TRPA1 O75762 3/20 0.39
MMP1 P03956 1/20 0.39
MMP2 P08253 1/20 0.39
MMP3 P08254 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12344936 0.90 TRPA1 (0.45) ENPEPHDAC3HDAC4HDAC1HDAC7
SCHEMBL21310677 0.83 ESR1 (0.50) TDP1HDAC3HDAC4HDAC1HDAC7
SCHEMBL23894335 0.82 TRPA1 (0.57) TRPA1APAF1ALDH1A1LMNA
SCHEMBL19257721 0.81 SLC6A3 (0.42) GRIA4SMN1; SMN2ALDH1A1LMNAESR1
SCHEMBL19257727 0.81 HDAC8 (0.40) ENPEPPOLBSMN1; SMN2TDP1HDAC3
SCHEMBL22267939 0.80 ALDH1A1 (0.38) ENPEPPOLBSMN1; SMN2TDP1HDAC3
SCHEMBL5691985 0.77 FFAR1 (0.59) GRIA4POLBSMN1; SMN2TDP1ALDH1A1
SCHEMBL5691981 0.77 FFAR1 (0.59) GRIA4POLBSMN1; SMN2TDP1ALDH1A1
SCHEMBL4129122 0.76 GRIA4 (0.43) GRIA4POLBTDP1TRPA1ALDH1A1
SCHEMBL15865877 0.75 MME (0.44) PTGS1PTGS2LMNACYP2C9AKR1C3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017134547-A1 TUBULYSIN ANALOGS AND METHODS FOR THEIR PREPARATION PFIZER INC. (US) 2017-08-10 WO disclosed