SCHEMBL19258286

SCHEMBL19258286

Cc1cc(C)c(C)c(-c2cc(CCC(F)(F)F)c3ccccc3n2)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACP1 P24666 4/20 0.38
ALDH1A1 P00352 5/20 0.36
TDP1 Q9NUW8 2/20 0.36
ALOX12 P18054 1/20 0.36
TLR8 Q9NR97 2/20 0.36
TLR7 Q9NYK1 2/20 0.36
KDM4E B2RXH2 2/20 0.36
SMN1; SMN2 Q16637 1/20 0.35
LMNA P02545 2/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
MAPT P10636 2/20 0.35
AR P10275 2/20 0.34
CYP1A2 P05177 2/20 0.34
PSMB5 P28074 1/20 0.34
HPGD P15428 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20809330 0.82 LMNA (0.40) ACP1ALDH1A1TDP1TLR8TLR7
SCHEMBL19258287 0.82 LMNA (0.39) ACP1ALDH1A1TDP1ALOX12KDM4E
SCHEMBL19807355 0.79 CYP1A2 (0.51) ALDH1A1TDP1KDM4ESMN1; SMN2LMNA
SCHEMBL18633428 0.79 ALDH1A1 (0.41) ALDH1A1TDP1ALOX12TLR8TLR7
SCHEMBL20809328 0.78 KMT2A (0.47) ACP1ALDH1A1TDP1ALOX12KDM4E
SCHEMBL20809331 0.77 ACHE (0.50) ACP1TLR8TLR7KDM4ESMN1; SMN2
SCHEMBL19258285 0.76 MEN1 (0.44) ACP1ALDH1A1KDM4ESMN1; SMN2LMNA
SCHEMBL20204409 0.74 ACACA (0.49) ACP1ALDH1A1TDP1KDM4ELMNA
SCHEMBL26060728 0.74 ACHE (0.37) ACHE
SCHEMBL21168730 0.72 ACACA (0.44) ALDH1A1KDM4ESMN1; SMN2LMNAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3205658-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES Universal Display Corporation (US) 2017-08-16 EP disclosed