Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.35 |
| ▸ | CCR4 | P51679 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13484393 | 0.87 | PTGS2 (0.34) | CA12CA1CA2CA4CA6 | |
| SCHEMBL3599216 | 0.87 | GPR119 (0.31) | CA12CA1CA2CA4CA6 | |
| SCHEMBL3599220 | 0.85 | ENPP2 (0.33) | PIK3CDPIP5K1CPIK3CBPI4KAPIK3CG | |
| SCHEMBL31035841 | 0.85 | ALOX5AP (0.40) | CA12CA1CA2CA4CA6 | |
| SCHEMBL422105 | 0.85 | SIRT6 (0.38) | PIK3CDPIP5K1CPIK3CBPI4KAPIK3CG | |
| SCHEMBL7045227 | 0.85 | ALOX5AP (0.40) | CA12CA1CA2CA4CA6 | |
| SCHEMBL423474 | 0.85 | CCR4 (0.31) | PIK3CDPIP5K1CPIK3CBPI4KAPIK3CG | |
| SCHEMBL19449825 | 0.82 | GPR119 (0.33) | PI4KBGPR119POLB | |
| SCHEMBL13837740 | 0.80 | HDAC8 (0.33) | — | |
| SCHEMBL21299359 | 0.80 | LOXL2 (0.35) | CA12CA1CA2CA4CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017143036-A1 | MODULATORS OF MS4A ACTIVITY | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-08-24 | — | — | WO | claimed |