Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 9/20 | 0.61 |
| ▸ | SRC | P12931 | 8/20 | 0.59 |
| ▸ | ABL1 | P00519 | 6/20 | 0.56 |
| ▸ | FLT3 | P36888 | 2/20 | 0.56 |
| ▸ | RET | P07949 | 2/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | PAK4 | O96013 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
| ▸ | PRKACA | P17612 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
| ▸ | LTK | P29376 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.56 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19264162 | 0.94 | SRC (0.61) | RIPK2SRCABL1FLT3RET | |
| SCHEMBL10261381 | 0.90 | FGR (0.57) | RIPK2SRCABL1FLT3RET | |
| SCHEMBL14644244 | 0.90 | RIPK2 (0.52) | RIPK2SRCABL1FLT3RET | |
| SCHEMBL10261916 | 0.86 | ADK (0.55) | RIPK2SRCABL1FLT3RET | |
| SCHEMBL19563041 | 0.86 | ADK (0.55) | RIPK2SRCABL1FLT3RET | |
| SCHEMBL14643787 | 0.86 | ADK (0.52) | RIPK2SRCABL1FLT3RET | |
| SCHEMBL14643106 | 0.86 | ADK (0.52) | RIPK2SRCABL1FLT3RET | |
| SCHEMBL24251908 | 0.84 | ADK (0.48) | RIPK2SRCABL1FLT3RET | |
| SCHEMBL23847697 | 0.84 | ADK (0.48) | RIPK2SRCABL1FLT3RET | |
| SCHEMBL23847617 | 0.83 | RIPK2 (0.47) | RIPK2SRCABL1FLT3RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021242505-A1 | INHIBITORS OF NEK7 KINASE | Halia Therapeutics, Inc. (US) | 2021-12-02 | — | — | WO | disclosed |