Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | DCLRE1A | Q6PJP8 | 1/20 | 0.49 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.49 |
| ▸ | ACLY | P53396 | 2/20 | 0.47 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.46 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.44 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 3/20 | 0.43 |
| ▸ | BRD2 | P25440 | 1/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.43 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1926320 | 0.87 | PTPN1 (0.51) | PTPN1DCLRE1ADCLRE1BACLYSLC6A9 | |
| SCHEMBL1926265 | 0.86 | PTPN1 (0.48) | PTPN1DCLRE1ADCLRE1BACLYSLC6A9 | |
| SCHEMBL14303478 | 0.82 | LMNA (0.49) | PTPN1PLK1BRD4BRD2BRD3 | |
| SCHEMBL3109472 | 0.80 | CAPN1 (0.57) | PLK1BRD4BRD2BRD3BRDT | |
| SCHEMBL2900959 | 0.79 | ALDH1A1 (0.60) | — | |
| SCHEMBL6988561 | 0.79 | CAPN1 (0.45) | PTPN1NR4A2ACMSDLIPG | |
| SCHEMBL14811488 | 0.78 | HDAC6 (0.54) | PTPN1 | |
| SCHEMBL12922046 | 0.78 | HDAC7 (0.55) | PTPN1NR4A2PLK1ACMSDEGFR | |
| SCHEMBL5491925 | 0.77 | SLC6A9 (0.48) | PTPN1DCLRE1ADCLRE1BACLYSLC6A9 | |
| SCHEMBL92217 | 0.77 | NR4A2 (0.51) | NR4A2PLK1ACMSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763509-B1 | ALPHA-HELICAL MIMETICS | WALTER & ELIZA HALL INST MEDICAL RES (AU) | 2018-02-21 | — | — | EP | disclosed |
| US-7956216-B2 | Benzoyl urea derivatives mimicing BH3-only proteins, able to interact with a Bcl-2 protein | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2011-06-07 | — | — | US | disclosed |
| US-20080153802-A1 | Alpha-helical mimetics | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2008-06-26 | — | — | US | disclosed |
| EP-1763509-A1 | ALPHA-HELICAL MIMETICS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006002474-A1 | ALPHA-HELICAL MIMETICS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153802-A1 | Alpha-helical mimetics | BID, BAX, BAD | PTPN1 3506/4885NR4A2 1827/4885DCLRE1A 1081/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.