Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.51 |
| ▸ | DCLRE1A | Q6PJP8 | 1/20 | 0.48 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.48 |
| ▸ | ACLY | P53396 | 6/20 | 0.46 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | BCL2 | P10415 | 1/20 | 0.42 |
| ▸ | HNF4A | P41235 | 1/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.41 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1927147 | 0.87 | PTPN1 (0.52) | PTPN1DCLRE1ADCLRE1BACLYACMSD | |
| SCHEMBL1926265 | 0.82 | PTPN1 (0.48) | PTPN1DCLRE1ADCLRE1BACLYACMSD | |
| SCHEMBL27929241 | 0.74 | DCLRE1B (0.52) | PTPN1DCLRE1ADCLRE1BACLYACMSD | |
| SCHEMBL5491925 | 0.73 | SLC6A9 (0.48) | PTPN1DCLRE1ADCLRE1BACLYACMSD | |
| SCHEMBL29738649 | 0.71 | MEN1 (0.62) | PTPN1ACMSDBCL2HNF4A | |
| SCHEMBL8992573 | 0.71 | MEN1 (0.62) | PTPN1ACMSDBCL2HNF4A | |
| SCHEMBL14303478 | 0.69 | LMNA (0.49) | PTPN1BCL2MPOPTPN2PTPN6 | |
| SCHEMBL6441850 | 0.68 | PTPN1 (0.62) | PTPN1ACMSDBCL2HNF4APTPN2 | |
| SCHEMBL9250813 | 0.68 | PTPN1 (1.00) | PTPN1ACMSDHNF4APTPN2PTPN6 | |
| SCHEMBL15264247 | 0.68 | GGPS1 (0.55) | PTPN1ACMSDSLC6A9BCL2PTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763509-B1 | ALPHA-HELICAL MIMETICS | WALTER & ELIZA HALL INST MEDICAL RES (AU) | 2018-02-21 | — | — | EP | disclosed |
| US-7956216-B2 | Benzoyl urea derivatives mimicing BH3-only proteins, able to interact with a Bcl-2 protein | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2011-06-07 | — | — | US | disclosed |
| US-20080153802-A1 | Alpha-helical mimetics | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2008-06-26 | — | — | US | disclosed |
| EP-1763509-A1 | ALPHA-HELICAL MIMETICS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006002474-A1 | ALPHA-HELICAL MIMETICS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153802-A1 | Alpha-helical mimetics | BID, BAX, BAD | PTPN1 3506/4885DCLRE1A 1081/4885DCLRE1B 2341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.